Intrinsic and acquired resistance to HER2-targeted therapies in HER2 gene-amplified breast cancer: mechanisms and clinical implications - Rexer, Brent N; Arteaga, Carlos L (Critical reviews in oncogenesis, 2012)
Keywords: Animals; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Breast Neoplasms - diagnosis; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Carcinoma - diagnosis; Carcinoma - drug therapy; Carcinoma - genetics; Drug Resistance, Neoplasm - drug effects; Drug Resistance, Neoplasm - genetics; Female; Gene Amplification - drug effects; Gene Amplification - physiology; Humans; Models, Biological; Molecular Targeted Therapy - methods; Prognosis; Protein Kinase Inhibitors - administration & dosage; Protein Kinase Inhibitors - therapeutic use; Receptor, ErbB-2 - antagonists & inhibitors; Receptor, ErbB-2 - genetics; Receptor, ErbB-2 - metabolism; Signal Transduction - drug effects; Signal Transduction - genetics