Inhibition of cell proliferation and induction of apoptosis by ExFABP gene targeting

• Published in: Journal of cellular physiology Vol. 196; no. 3; pp. 464 - 473
• Main Authors: Di Marco, Eddi, Sessarego, Nadia, Zerega, Barbara, Cancedda, Ranieri, Descalzi Cancedda, Fiorella
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2003
• Subjects: Animals; Apoptosis; Avian Proteins; Carrier Proteins - antagonists & inhibitors; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell Differentiation; Cell Division; Cell Survival; Chick Embryo; Chondrocytes - cytology; Chondrocytes - metabolism; DNA, Antisense - genetics; DNA, Antisense - metabolism; DNA, Complementary - genetics; DNA, Complementary - metabolism; Fatty Acid-Binding Proteins; Gene Expression Regulation - drug effects; Gene Targeting; Lipocalins; Lipopolysaccharides - pharmacology; Liver - drug effects; Liver - metabolism; Myoblasts - cytology; Myoblasts - metabolism

Ex‐FABP, an extracellular fatty acid binding lipocalin, is physiologically expressed by differentiating chicken chondrocytes and myoblasts. Its expression is enhanced after cell treatment with inflammatory stimuli and repressed by anti‐inflammatory agents, behaving as an acute phase protein. Chicken...