Comparative Experimental Pharmacokinetics of Benzimidazole Derivatives

Comparative study of experimental kinetics of distribution of benzimidazole derivatives (bemithyl, etomerzole, and thietazole) in organs and tissues was carried out after single and course treatment. The drugs intensely passed into organs and tissues from the blood after treatment by all protocols....

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Bibliographic Details
Published inBulletin of experimental biology and medicine Vol. 146; no. 6; pp. 750 - 752
Main Authors Sergeeva, S. A, Gulyaeva, I. L
Format Journal Article
LanguageEnglish
Russian
Published Boston Boston : Springer US 01.12.2008
Springer US
Springer Nature B.V
Subjects
Animals
Antioxidants - pharmacokinetics
bemithyl
Benzimidazoles - blood
Benzimidazoles - chemistry
Benzimidazoles - pharmacokinetics
Biomedical and Life Sciences
Biomedicine
Cell Biology
Chromatography, Gas
distribution
etomerzole
Internal Medicine
Laboratory Medicine
Pathology
pharmacokinetics
Pharmacology and Toxicology
Rats
thietazole
Tissue Distribution
bemithyl
pharmacokinetics
thietazole
distribution
etomerzole
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Summary:Comparative study of experimental kinetics of distribution of benzimidazole derivatives (bemithyl, etomerzole, and thietazole) in organs and tissues was carried out after single and course treatment. The drugs intensely passed into organs and tissues from the blood after treatment by all protocols. Specific features of drug distribution were detected; for example, splenic tissue selectively accumulated thietazole during course treatment.
Bibliography:http://dx.doi.org/10.1007/s10517-009-0382-9
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-009-0382-9