Metformin prevents ischemia reperfusion-induced oxidative stress in the fatty liver by attenuation of reactive oxygen species formation

• Published in: American journal of physiology: Gastrointestinal and liver physiology Vol. 309; no. 2; pp. G100 - G111
• Main Authors: Cahova, Monika, Palenickova, Eliska, Dankova, Helena, Sticova, Eva, Burian, Martin, Drahota, Zdenek, Cervinkova, Zuzana, Kucera, Otto, Gladkova, Christina, Stopka, Pavel, Krizova, Jana, Papackova, Zuzana, Oliyarnyk, Olena, Kazdova, Ludmila
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 15.07.2015
• Subjects: Adenosine Triphosphate - metabolism; Animals; Anti-Inflammatory Agents - pharmacology; Antioxidants; Antioxidants - pharmacology; Apoptosis - drug effects; Cytoprotection; Diet, High-Fat; Disease Models, Animal; DNA damage; Energy Metabolism - drug effects; Enzymes; Inflammation Mediators - metabolism; Lipid Peroxidation - drug effects; Liver - drug effects; Liver - metabolism; Liver - pathology; Liver diseases; Male; Metformin - pharmacology; Mitochondria; Mitochondria, Liver - drug effects; Mitochondria, Liver - metabolism; Mitochondria, Liver - pathology; Non-alcoholic Fatty Liver Disease - drug therapy; Non-alcoholic Fatty Liver Disease - etiology; Non-alcoholic Fatty Liver Disease - metabolism; Non-alcoholic Fatty Liver Disease - pathology; Oxidative stress; Oxidative Stress - drug effects; Physiology; Rats, Wistar; Reactive Oxygen Species - metabolism; Reperfusion Injury - etiology; Reperfusion Injury - metabolism; Reperfusion Injury - pathology; Reperfusion Injury - prevention & control; Time Factors; metformin; liver injury; 31P MR spectroscopy; oxidative stress; mitochondrial respiration

Nonalcoholic fatty liver disease is associated with chronic oxidative stress. In our study, we explored the antioxidant effect of antidiabetic metformin on chronic [high-fat diet (HFD)-induced] and acute oxidative stress induced by short-term warm partial ischemia-reperfusion (I/R) or on a combinati...