The role of antidrug antibodies in ustekinumab therapy and the impact of methotrexate

• Published in: Rheumatology (Oxford, England) Vol. 62; no. 12; pp. 3993 - 3999
• Main Authors: Mojtahed Poor, Sorwe, Henke, Marina, Ulshöfer, Thomas, Köhm, Michaela, Behrens, Frank, Burkhardt, Harald, Schiffmann, Susanne
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.12.2023
• Subjects: Antirheumatic Agents - adverse effects; Arthritis, Psoriatic - chemically induced; Arthritis, Psoriatic - drug therapy; Drug Therapy, Combination; Humans; Methotrexate - therapeutic use; Treatment Outcome; Ustekinumab - therapeutic use; MTX; ustekinumab; immunogenicity; antidrug antibodies; PsA

Abstract Objective We investigated the impact of concomitant MTX on ustekinumab (UST) levels and antidrug antibody (ADA) formation in PsA and evaluated consequences in pharmacodynamics and pharmacokinetics. Methods We conducted a post-hoc analysis on 112 PsA serum samples of subjects treated with op...