Stereotyped B-cell response that counteracts antigenic variation of influenza viruses

• Published in: International immunology Vol. 32; no. 9; pp. 613 - 621
• Main Authors: Tonouchi, Keisuke, Adachi, Yu, Moriyama, Saya, Sano, Kaori, Tabata, Koshiro, Ide, Keigo, Takeyama, Haruko, Suzuki, Tadaki, Takahashi, Yoshimasa
• Format: Journal Article
• Language: English
• Published: UK Oxford University Press 08.09.2020
• Subjects: non-neutralizing antibodies; Fc-dependent; vaccine; cross-group; germinal center

Abstract Influenza A subtypes are categorized into group 1 and group 2 based on the hemagglutinin (HA) sequence. Owing to the phylogenetic distance of HAs in different groups, antibodies that bind multiple HA subtypes across different groups are extremely rare. In this study, we demonstrated that an...