Stereotyped B-cell response that counteracts antigenic variation of influenza viruses
Abstract Influenza A subtypes are categorized into group 1 and group 2 based on the hemagglutinin (HA) sequence. Owing to the phylogenetic distance of HAs in different groups, antibodies that bind multiple HA subtypes across different groups are extremely rare. In this study, we demonstrated that an...
Saved in:
| Published in | International immunology Vol. 32; no. 9; pp. 613 - 621 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
UK
Oxford University Press
08.09.2020
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Abstract
Influenza A subtypes are categorized into group 1 and group 2 based on the hemagglutinin (HA) sequence. Owing to the phylogenetic distance of HAs in different groups, antibodies that bind multiple HA subtypes across different groups are extremely rare. In this study, we demonstrated that an immunization with acid-treated HA antigen elicits germinal center (GC) B cells that bind multiple HA subtypes in both group 1 and group 2. The cross-group GC B cells utilized mostly one VH gene (1S56) and exhibited a sign of clonal evolution within GCs. The 1S56-lineage IgGs derived from GC B cells were able to bind to HA protein on the infected cell surface but not to the native form of HA protein, suggesting the cryptic nature of the 1S56 epitope and its exposure in infected cells. Finally, the 1S56-lineage IgGs provided protection against lethal infection in an Fc-dependent manner, independent of the virus-neutralizing activity. Thus, we identified 1S56-lineage antibodies as a unique stereotype for achieving cross-group influenza specificity. The antigens exposing the 1S56 epitope may be good candidates for broadly protective immunogens. |
|---|---|
| AbstractList | Influenza A subtypes are categorized into group 1 and group 2 based on the hemagglutinin (HA) sequence. Owing to the phylogenetic distance of HAs in different groups, antibodies that bind multiple HA subtypes across different groups are extremely rare. In this study, we demonstrated that an immunization with acid-treated HA antigen elicits germinal center (GC) B cells that bind multiple HA subtypes in both group 1 and group 2. The cross-group GC B cells utilized mostly one VH gene (1S56) and exhibited a sign of clonal evolution within GCs. The 1S56-lineage IgGs derived from GC B cells were able to bind to HA protein on the infected cell surface but not to the native form of HA protein, suggesting the cryptic nature of the 1S56 epitope and its exposure in infected cells. Finally, the 1S56-lineage IgGs provided protection against lethal infection in an Fc-dependent manner, independent of the virus-neutralizing activity. Thus, we identified 1S56-lineage antibodies as a unique stereotype for achieving cross-group influenza specificity. The antigens exposing the 1S56 epitope may be good candidates for broadly protective immunogens. Abstract Influenza A subtypes are categorized into group 1 and group 2 based on the hemagglutinin (HA) sequence. Owing to the phylogenetic distance of HAs in different groups, antibodies that bind multiple HA subtypes across different groups are extremely rare. In this study, we demonstrated that an immunization with acid-treated HA antigen elicits germinal center (GC) B cells that bind multiple HA subtypes in both group 1 and group 2. The cross-group GC B cells utilized mostly one VH gene (1S56) and exhibited a sign of clonal evolution within GCs. The 1S56-lineage IgGs derived from GC B cells were able to bind to HA protein on the infected cell surface but not to the native form of HA protein, suggesting the cryptic nature of the 1S56 epitope and its exposure in infected cells. Finally, the 1S56-lineage IgGs provided protection against lethal infection in an Fc-dependent manner, independent of the virus-neutralizing activity. Thus, we identified 1S56-lineage antibodies as a unique stereotype for achieving cross-group influenza specificity. The antigens exposing the 1S56 epitope may be good candidates for broadly protective immunogens. Influenza A subtypes are categorized into group 1 and group 2 based on the hemagglutinin (HA) sequence. Owing to the phylogenetic distance of HAs in different groups, antibodies that bind multiple HA subtypes across different groups are extremely rare. In this study, we demonstrated that an immunization with acid-treated HA antigen elicits germinal center (GC) B cells that bind multiple HA subtypes in both group 1 and group 2. The cross-group GC B cells utilized mostly one VH gene (1S56) and exhibited a sign of clonal evolution within GCs. The 1S56-lineage IgGs derived from GC B cells were able to bind to HA protein on the infected cell surface but not to the native form of HA protein, suggesting the cryptic nature of the 1S56 epitope and its exposure in infected cells. Finally, the 1S56-lineage IgGs provided protection against lethal infection in an Fc-dependent manner, independent of the virus-neutralizing activity. Thus, we identified 1S56-lineage antibodies as a unique stereotype for achieving cross-group influenza specificity. The antigens exposing the 1S56 epitope may be good candidates for broadly protective immunogens.Influenza A subtypes are categorized into group 1 and group 2 based on the hemagglutinin (HA) sequence. Owing to the phylogenetic distance of HAs in different groups, antibodies that bind multiple HA subtypes across different groups are extremely rare. In this study, we demonstrated that an immunization with acid-treated HA antigen elicits germinal center (GC) B cells that bind multiple HA subtypes in both group 1 and group 2. The cross-group GC B cells utilized mostly one VH gene (1S56) and exhibited a sign of clonal evolution within GCs. The 1S56-lineage IgGs derived from GC B cells were able to bind to HA protein on the infected cell surface but not to the native form of HA protein, suggesting the cryptic nature of the 1S56 epitope and its exposure in infected cells. Finally, the 1S56-lineage IgGs provided protection against lethal infection in an Fc-dependent manner, independent of the virus-neutralizing activity. Thus, we identified 1S56-lineage antibodies as a unique stereotype for achieving cross-group influenza specificity. The antigens exposing the 1S56 epitope may be good candidates for broadly protective immunogens. |
| Author | Tabata, Koshiro Moriyama, Saya Tonouchi, Keisuke Sano, Kaori Suzuki, Tadaki Takahashi, Yoshimasa Adachi, Yu Ide, Keigo Takeyama, Haruko |
| Author_xml | – sequence: 1 givenname: Keisuke surname: Tonouchi fullname: Tonouchi, Keisuke organization: Department of Immunology, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan – sequence: 2 givenname: Yu surname: Adachi fullname: Adachi, Yu organization: Department of Immunology, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan – sequence: 3 givenname: Saya surname: Moriyama fullname: Moriyama, Saya organization: Department of Immunology, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan – sequence: 4 givenname: Kaori surname: Sano fullname: Sano, Kaori organization: Department of Pathology, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan – sequence: 5 givenname: Koshiro surname: Tabata fullname: Tabata, Koshiro organization: Department of Pathology, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan – sequence: 6 givenname: Keigo surname: Ide fullname: Ide, Keigo organization: Department of Life Science and Medical Bioscience, Waseda University, Shinjuku, Tokyo, Japan – sequence: 7 givenname: Haruko surname: Takeyama fullname: Takeyama, Haruko organization: Department of Life Science and Medical Bioscience, Waseda University, Shinjuku, Tokyo, Japan – sequence: 8 givenname: Tadaki surname: Suzuki fullname: Suzuki, Tadaki organization: Department of Pathology, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan – sequence: 9 givenname: Yoshimasa surname: Takahashi fullname: Takahashi, Yoshimasa email: ytakahas@niid.go.jp organization: Department of Immunology, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32504541$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkM1LxDAQxYOs6Ppx9Sg56qFu0mT7cdTFL1jwoJ7DNJ1qpE1qkor611vdFUQQT_Ngfm-G93bIxDqLhBxwdsJZKWbGRtN1s_oVgIlig0y5zFiSijyf_NDbZCeEJ8aYSEuxRbZFOmdyLvmU3N9G9OjiW481PUs0ti31GHpnA9L4CJFqN9iRAR0DhfHbA1qj6Qt4A9E4S11DjW3aAe070Bfjh4Bhj2w20AbcX89dcn9xfre4SpY3l9eL02WiRSliglmBoJsmZXUNBed5WWrQYlymGSs04Cg1F3ldQpXLSs9z4HlWFRqhkrWWYpccre723j0PGKLqTPjMABbdEFQqORNSsoyN6OEaHaoOa9V704F_U99VjIBcAdq7EDw2Spv4FTF6MK3iTH02rlaNq3Xjo-3kl-378p-G45XBDf1_7AcZ0Jca |
| CitedBy_id | crossref_primary_10_1016_j_vaccine_2023_06_019 crossref_primary_10_1016_j_bbrc_2023_06_067 crossref_primary_10_1073_pnas_2316964120 crossref_primary_10_1093_intimm_dxaa056 |
| Cites_doi | 10.1126/science.1171491 10.1016/j.cell.2016.06.043 10.1038/nm.3927 10.1016/j.cell.2019.03.048 10.1073/pnas.1013387107 10.1126/sciadv.aav1882 10.1016/j.coviro.2017.03.002 10.1038/s41467-019-11821-6 10.1038/s41467-017-00928-3 10.1016/j.chom.2019.04.003 10.1038/ncomms8708 10.1016/j.cell.2019.04.011 10.1038/nm.3443 10.1074/jbc.M116.767749 10.1128/JVI.05397-11 10.1371/journal.ppat.1007427 10.1371/journal.ppat.1005578 10.1371/journal.ppat.1000796 10.1093/molbev/msy020 10.1016/j.immuni.2017.12.009 10.1093/infdis/jiy103 10.1016/j.cell.2018.05.050 10.1126/science.aac7263 10.1038/nm.4224 10.1016/j.chom.2016.05.014 10.1126/science.1222908 10.1371/journal.ppat.1000350 10.4049/jimmunol.1402835 10.1073/pnas.1115369109 10.1128/jvi.67.5.2552-2558.1993 10.1126/science.1205669 10.1016/j.jim.2009.08.009 10.1038/nature11371 10.1084/jem.20142284 10.1016/j.cell.2016.05.073 10.1128/JVI.05193-11 10.1086/598954 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2020. Published by Oxford University Press on behalf of The Japanese Society for Immunology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2020 The Japanese Society for Immunology. 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
| Copyright_xml | – notice: The Author(s) 2020. Published by Oxford University Press on behalf of The Japanese Society for Immunology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2020 – notice: The Japanese Society for Immunology. 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
| DBID | AAYXX CITATION NPM 7X8 |
| DOI | 10.1093/intimm/dxaa038 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed CrossRef MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Biology |
| DocumentTitleAlternate | Special Issue: Memory and Vaccination |
| EISSN | 1460-2377 |
| EndPage | 621 |
| ExternalDocumentID | 32504541 10_1093_intimm_dxaa038 10.1093/intimm/dxaa038 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- -E4 .2P .55 .GJ .I3 .ZR 0R~ 18M 1TH 29J 2WC 4.4 482 48X 53G 5GY 5RE 5VS 5WA 5WD 70D A8Z AABZA AACZT AAIMJ AAJKP AAJQQ AAMDB AAMVS AAOGV AAPGJ AAPNW AAPQZ AAPXW AARHZ AAUAY AAUQX AAVAP AAVLN AAWDT ABDFA ABEJV ABEUO ABGNP ABIME ABIXL ABJNI ABKDP ABMNT ABNGD ABNHQ ABNKS ABOCM ABPIB ABPQP ABPTD ABQLI ABQNK ABQTQ ABSMQ ABVGC ABWST ABXVV ABXZS ABZBJ ABZEO ACFRR ACGFO ACGFS ACIWK ACPQN ACPRK ACUFI ACUKT ACUTJ ACUTO ACVCV ACYHN ACZBC ADBBV ADEYI ADEZT ADFTL ADGKP ADGZP ADHKW ADHZD ADIPN ADMTO ADNBA ADOCK ADQBN ADRTK ADVEK ADYVW ADZTZ ADZXQ AEGPL AEGXH AEHUL AEJOX AEKPW AEKSI AELWJ AEMDU AEMQT AENEX AENZO AEPUE AETBJ AEWNT AFFNX AFFQV AFFZL AFGWE AFIYH AFOFC AFRAH AFSHK AFXAL AFYAG AGINJ AGKEF AGKRT AGMDO AGQXC AGSYK AGUTN AHMBA AHMMS AHXPO AI. AIAGR AIJHB AJDVS AJEEA AJNCP AKHUL AKWXX ALMA_UNASSIGNED_HOLDINGS ALUQC ALXQX ANFBD APIBT APJGH APWMN AQDSO AQKUS ARIXL ASAOO ASPBG ATDFG ATGXG ATTQO AVNTJ AVWKF AXUDD AYOIW AZFZN BAWUL BAYMD BCRHZ BEYMZ BHONS BQDIO BSWAC BTRTY BVRKM BZKNY C1A C45 CAG CDBKE COF CS3 CXTWN CZ4 DAKXR DFGAJ DIK DILTD DU5 D~K E3Z EBD EBS EE~ EIHJH EJD ELUNK EMOBN ENERS F5P F9B FECEO FEDTE FHSFR FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H13 H5~ HAR HVGLF HW0 HZ~ IH2 IOX J21 J8S JXSIZ KAQDR KBUDW KOP KQ8 KSI KSN M-Z M49 MBLQV MBTAY MHKGH N9A NGC NLBLG NOMLY NOYVH NTWIH NU- NVLIB O0~ O9- OAUYM OAWHX OBC OBFPC OBOKY OBS OCZFY ODMLO OEB OJQWA OJZSN OK1 OPAEJ OVD OWPYF O~Y P2P PAFKI PB- PEELM PQQKQ Q1. Q5Y QBD R44 RD5 RIG RNI ROL ROX ROZ RUSNO RW1 RXO RZF RZO SV3 TCN TEORI TJX TLC TMA TR2 UDS VH1 W8F WOQ X7H X7M Y6R YAYTL YHZ YKOAZ YXANX ZKX ~91 AAYXX AGORE AHGBF AJBYB CITATION NPM 7X8 |
| ID | FETCH-LOGICAL-c393t-e68eacff20dda811799cac3c392608cae3c3c137d9ab74bc57a176b8ceab4dc43 |
| ISSN | 1460-2377 |
| IngestDate | Fri Jul 11 02:08:40 EDT 2025 Thu Apr 03 06:58:26 EDT 2025 Tue Jul 01 00:40:40 EDT 2025 Thu Apr 24 23:06:13 EDT 2025 Wed Apr 02 07:05:01 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 9 |
| Keywords | non-neutralizing antibodies Fc-dependent vaccine cross-group germinal center |
| Language | English |
| License | This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model The Japanese Society for Immunology. 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c393t-e68eacff20dda811799cac3c392608cae3c3c137d9ab74bc57a176b8ceab4dc43 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://academic.oup.com/intimm/article-pdf/32/9/613/33727671/dxaa038.pdf |
| PMID | 32504541 |
| PQID | 2410344060 |
| PQPubID | 23479 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_2410344060 pubmed_primary_32504541 crossref_citationtrail_10_1093_intimm_dxaa038 crossref_primary_10_1093_intimm_dxaa038 oup_primary_10_1093_intimm_dxaa038 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2020-09-08 |
| PublicationDateYYYYMMDD | 2020-09-08 |
| PublicationDate_xml | – month: 09 year: 2020 text: 2020-09-08 day: 08 |
| PublicationDecade | 2020 |
| PublicationPlace | UK |
| PublicationPlace_xml | – name: UK – name: England |
| PublicationTitle | International immunology |
| PublicationTitleAlternate | Int Immunol |
| PublicationYear | 2020 |
| Publisher | Oxford University Press |
| Publisher_xml | – name: Oxford University Press |
| References | Okuno (2022070717273260300_CIT0007) 1993; 67 Lo (2022070717273260300_CIT0026) 2017; 292 Dreyfus (2022070717273260300_CIT0004) 2012; 337 Takahashi (2022070717273260300_CIT0020) 2009; 199 Saito (2022070717273260300_CIT0022) 2019; 15 DeWitt (2022070717273260300_CIT0025) 2018; 35 Tiller (2022070717273260300_CIT0024) 2009; 350 Ohshima (2022070717273260300_CIT0009) 2011; 85 Watanabe (2022070717273260300_CIT0015) 2019; 177 McCarthy (2022070717273260300_CIT0008) 2018; 48 Corti (2022070717273260300_CIT0001) 2017; 24 Tzarum (2022070717273260300_CIT0032) 2019; 5 Lingwood (2022070717273260300_CIT0011) 2012; 489 Corti (2022070717273260300_CIT0003) 2011; 333 Kallewaard (2022070717273260300_CIT0006) 2016; 166 Bajic (2022070717273260300_CIT0013) 2019; 25 Adachi (2022070717273260300_CIT0028) 2015; 212 Tan (2022070717273260300_CIT0035) 2016; 12 Ekiert (2022070717273260300_CIT0005) 2009; 324 Yoshida (2022070717273260300_CIT0010) 2009; 5 Impagliazzo (2022070717273260300_CIT0029) 2015; 349 Onodera (2022070717273260300_CIT0021) 2012; 109 Wheatley (2022070717273260300_CIT0012) 2015; 195 Wang (2022070717273260300_CIT0017) 2010; 107 Adachi (2022070717273260300_CIT0016) 2019; 10 Wang (2022070717273260300_CIT0018) 2010; 6 Das (2022070717273260300_CIT0019) 2018; 174 Joyce (2022070717273260300_CIT0023) 2016; 166 He (2022070717273260300_CIT0034) 2017; 8 Wu (2022070717273260300_CIT0036) 2015; 6 Yassine (2022070717273260300_CIT0030) 2015; 21 DiLillo (2022070717273260300_CIT0031) 2014; 20 Terajima (2022070717273260300_CIT0037) 2011; 85 Henry Dunand (2022070717273260300_CIT0033) 2016; 19 Lee (2022070717273260300_CIT0027) 2016; 22 Erbelding (2022070717273260300_CIT0002) 2018; 218 Bangaru (2022070717273260300_CIT0014) 2019; 177 |
| References_xml | – volume: 324 start-page: 246 year: 2009 ident: 2022070717273260300_CIT0005 article-title: Antibody recognition of a highly conserved influenza virus epitope publication-title: Science doi: 10.1126/science.1171491 – volume: 166 start-page: 609 year: 2016 ident: 2022070717273260300_CIT0023 article-title: Vaccine-induced antibodies that neutralize group 1 and Group 2 influenza A viruses publication-title: Cell doi: 10.1016/j.cell.2016.06.043 – volume: 21 start-page: 1065 year: 2015 ident: 2022070717273260300_CIT0030 article-title: Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection publication-title: Nat. Med doi: 10.1038/nm.3927 – volume: 177 start-page: 1124 year: 2019 ident: 2022070717273260300_CIT0015 article-title: Antibodies to a conserved influenza head interface epitope protect by an IgG subtype-dependent mechanism publication-title: Cell doi: 10.1016/j.cell.2019.03.048 – volume: 107 start-page: 18979 year: 2010 ident: 2022070717273260300_CIT0017 article-title: Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1013387107 – volume: 5 start-page: eaav1882 year: 2019 ident: 2022070717273260300_CIT0032 article-title: Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies publication-title: Sci. Adv doi: 10.1126/sciadv.aav1882 – volume: 24 start-page: 60 year: 2017 ident: 2022070717273260300_CIT0001 article-title: Tackling influenza with broadly neutralizing antibodies publication-title: Curr. Opin. Virol doi: 10.1016/j.coviro.2017.03.002 – volume: 10 start-page: 3883 year: 2019 ident: 2022070717273260300_CIT0016 article-title: Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies publication-title: Nat. Commun doi: 10.1038/s41467-019-11821-6 – volume: 8 start-page: 846 year: 2017 ident: 2022070717273260300_CIT0034 article-title: Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice publication-title: Nat. Commun doi: 10.1038/s41467-017-00928-3 – volume: 25 start-page: 827 year: 2019 ident: 2022070717273260300_CIT0013 article-title: Influenza antigen engineering focuses immune responses to a subdominant but broadly protective viral epitope publication-title: Cell Host Microbe doi: 10.1016/j.chom.2019.04.003 – volume: 6 start-page: 7708 year: 2015 ident: 2022070717273260300_CIT0036 article-title: A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus publication-title: Nat. Commun doi: 10.1038/ncomms8708 – volume: 177 start-page: 1136 year: 2019 ident: 2022070717273260300_CIT0014 article-title: A site of vulnerability on the influenza virus hemagglutinin head domain trimer interface publication-title: Cell doi: 10.1016/j.cell.2019.04.011 – volume: 20 start-page: 143 year: 2014 ident: 2022070717273260300_CIT0031 article-title: Broadly neutralizing hemagglutinin stalk-specific antibodies require FcγR interactions for protection against influenza virus in vivo publication-title: Nat. Med doi: 10.1038/nm.3443 – volume: 292 start-page: 3900 year: 2017 ident: 2022070717273260300_CIT0026 article-title: Effector-attenuating substitutions that maintain antibody stability and reduce toxicity in mice publication-title: J. Biol. Chem doi: 10.1074/jbc.M116.767749 – volume: 85 start-page: 11048 year: 2011 ident: 2022070717273260300_CIT0009 article-title: Naturally occurring antibodies in humans can neutralize a variety of influenza virus strains, including H3, H1, H2, and H5 publication-title: J. Virol doi: 10.1128/JVI.05397-11 – volume: 15 start-page: e1007427 year: 2019 ident: 2022070717273260300_CIT0022 article-title: IgA tetramerization improves target breadth but not peak potency of functionality of anti-influenza virus broadly neutralizing antibody publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1007427 – volume: 12 start-page: e1005578 year: 2016 ident: 2022070717273260300_CIT0035 article-title: Broadly-reactive neutralizing and non-neutralizing antibodies directed against the H7 influenza virus hemagglutinin reveal divergent mechanisms of protection publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1005578 – volume: 6 start-page: e1000796 year: 2010 ident: 2022070717273260300_CIT0018 article-title: Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1000796 – volume: 35 start-page: 1253 year: 2018 ident: 2022070717273260300_CIT0025 article-title: Using genotype abundance to improve phylogenetic inference publication-title: Mol. Biol. Evol doi: 10.1093/molbev/msy020 – volume: 48 start-page: 174 year: 2018 ident: 2022070717273260300_CIT0008 article-title: Memory B cells that cross-react with group 1 and group 2 influenza A viruses are abundant in adult human repertoires publication-title: Immunity doi: 10.1016/j.immuni.2017.12.009 – volume: 218 start-page: 347 year: 2018 ident: 2022070717273260300_CIT0002 article-title: A universal influenza vaccine: the strategic plan for the National Institute of Allergy and Infectious Diseases publication-title: J. Infect. Dis doi: 10.1093/infdis/jiy103 – volume: 174 start-page: 926 year: 2018 ident: 2022070717273260300_CIT0019 article-title: Direct visualization of the conformational dynamics of single influenza hemagglutinin trimers publication-title: Cell doi: 10.1016/j.cell.2018.05.050 – volume: 349 start-page: 1301 year: 2015 ident: 2022070717273260300_CIT0029 article-title: A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen publication-title: Science doi: 10.1126/science.aac7263 – volume: 22 start-page: 1456 year: 2016 ident: 2022070717273260300_CIT0027 article-title: Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination publication-title: Nat. Med doi: 10.1038/nm.4224 – volume: 19 start-page: 800 year: 2016 ident: 2022070717273260300_CIT0033 article-title: Both neutralizing and non-neutralizing human H7N9 influenza vaccine-induced monoclonal antibodies confer protection publication-title: Cell Host Microbe doi: 10.1016/j.chom.2016.05.014 – volume: 337 start-page: 1343 year: 2012 ident: 2022070717273260300_CIT0004 article-title: Highly conserved protective epitopes on influenza B viruses publication-title: Science doi: 10.1126/science.1222908 – volume: 5 start-page: e1000350 year: 2009 ident: 2022070717273260300_CIT0010 article-title: Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza A viruses publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1000350 – volume: 195 start-page: 602 year: 2015 ident: 2022070717273260300_CIT0012 article-title: H5N1 vaccine-elicited memory B cells are genetically constrained by the IGHV locus in the recognition of a neutralizing epitope in the hemagglutinin stem publication-title: J. Immunol doi: 10.4049/jimmunol.1402835 – volume: 109 start-page: 2485 year: 2012 ident: 2022070717273260300_CIT0021 article-title: Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1115369109 – volume: 67 start-page: 2552 year: 1993 ident: 2022070717273260300_CIT0007 article-title: A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains publication-title: J. Virol doi: 10.1128/jvi.67.5.2552-2558.1993 – volume: 333 start-page: 850 year: 2011 ident: 2022070717273260300_CIT0003 article-title: A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins publication-title: Science doi: 10.1126/science.1205669 – volume: 350 start-page: 183 year: 2009 ident: 2022070717273260300_CIT0024 article-title: Cloning and expression of murine Ig genes from single B cells publication-title: J. Immunol. Methods doi: 10.1016/j.jim.2009.08.009 – volume: 489 start-page: 566 year: 2012 ident: 2022070717273260300_CIT0011 article-title: Structural and genetic basis for development of broadly neutralizing influenza antibodies publication-title: Nature doi: 10.1038/nature11371 – volume: 212 start-page: 1709 year: 2015 ident: 2022070717273260300_CIT0028 article-title: Distinct germinal center selection at local sites shapes memory B cell response to viral escape publication-title: J. Exp. Med doi: 10.1084/jem.20142284 – volume: 166 start-page: 596 year: 2016 ident: 2022070717273260300_CIT0006 article-title: Structure and function analysis of an antibody recognizing all influenza a subtypes publication-title: Cell doi: 10.1016/j.cell.2016.05.073 – volume: 85 start-page: 13463 year: 2011 ident: 2022070717273260300_CIT0037 article-title: Complement-dependent lysis of influenza a virus-infected cells by broadly cross-reactive human monoclonal antibodies publication-title: J. Virol doi: 10.1128/JVI.05193-11 – volume: 199 start-page: 1629 year: 2009 ident: 2022070717273260300_CIT0020 article-title: Protective immunity afforded by inactivated H5N1 (NIBRG-14) vaccine requires antibodies against both hemagglutinin and neuraminidase in mice publication-title: J. Infect. Dis doi: 10.1086/598954 |
| SSID | ssj0003293 |
| Score | 2.3344843 |
| Snippet | Abstract
Influenza A subtypes are categorized into group 1 and group 2 based on the hemagglutinin (HA) sequence. Owing to the phylogenetic distance of HAs in... Influenza A subtypes are categorized into group 1 and group 2 based on the hemagglutinin (HA) sequence. Owing to the phylogenetic distance of HAs in different... |
| SourceID | proquest pubmed crossref oup |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 613 |
| Title | Stereotyped B-cell response that counteracts antigenic variation of influenza viruses |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/32504541 https://www.proquest.com/docview/2410344060 |
| Volume | 32 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF6FIhAXBOUVXloQEofIdJ318wiIqlCVSxOpnKx9RXKhNkrsiuTXM-vZrBPaisLFsuy1I818np2ZzHxDyBseq1SyUAdxltqWnJwFUoegEMXZjAmZ59r2Ox99TQ6m0ZeT-GQwWG12lzTynVpd2lfyP1qFa6BX2yX7D5r1L4ULcA76hSNoGI7X0vExCMXUNouqRx8Cm4MfzbHm1YBDCaF_NwnC2EYoS8XcWObNUo3OIT72nmKJU0pWYnReztuFKyk87Qvc-3xhaXtJttLwk7qq7TQV7PApF-33HkFauBvfWq_Vel4uxZnAVPTS7wjHohsAPjoUsGAzDwFBp_1XJeuj1sv7G3GbQdsaJSwYcze1xRnfPrnZrsvL0ZIm2KLqNuUE26gv2HvkwipBgGfw-ezrX0IwZIv5g0X76sU3yM0xhBhdOP750O_iHPwgT_LJ9_CpPffMlhOz1Rh5IT7p_JTJPXLXBRj0PaLlPhmYapfcwpGjy11y-8gVUzwg0w34UIQPXcOHWvjQDfhQDx_q4UPrGfXwoQ4-D8l0_9Pk40HgpmwEiue8CUySweY7m42Z1iLrGAKVUBxuQqibKWHgVIU81bmQaSRVnIowTWSmjJCRVhF_RHaqujJPCI0YB5sgNJcsiwyLRW6pnHIZ2a1Ej_MhCdZiK5SjoLeTUH4UWArBCxRz4cQ8JG_9-p9IvnLlyteghb8uerVWUgFG1IpVVKZuFwW4sZb6kiVsSB6j9vy7uCX5i6Pw6XV-4hm5038bz8lOM2_NC_BaG_myg9dvQDqkMA |
| linkProvider | Flying Publisher |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Stereotyped+B-cell+response+that+counteracts+antigenic+variation+of+influenza+viruses&rft.jtitle=International+immunology&rft.au=Tonouchi%2C+Keisuke&rft.au=Adachi%2C+Yu&rft.au=Moriyama%2C+Saya&rft.au=Sano%2C+Kaori&rft.date=2020-09-08&rft.pub=Oxford+University+Press&rft.eissn=1460-2377&rft.volume=32&rft.issue=9&rft.spage=613&rft.epage=621&rft_id=info:doi/10.1093%2Fintimm%2Fdxaa038&rft.externalDocID=10.1093%2Fintimm%2Fdxaa038 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1460-2377&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1460-2377&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1460-2377&client=summon |