Ileal Gene Expression Data from Crohn’s Disease Small Bowel Resections Indicate Distinct Clinical Subgroups

• Published in: Journal of Crohn's and colitis Vol. 13; no. 8; pp. 1055 - 1066
• Main Authors: Potdar, Alka A, Li, Dalin, Haritunians, Talin, VanDussen, Kelli L, Fiorino, Marie F, Liu, Ta-Chiang, Stappenbeck, Thaddeus S, Fleshner, Phillip, Targan, Stephan R, McGovern, Dermot P B, Bilsborough, Janine
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 14.08.2019
• Subjects: Adolescent; Adult; Anti-Inflammatory Agents - pharmacology; Child; Crohn Disease - diagnosis; Crohn Disease - epidemiology; Crohn Disease - genetics; Crohn Disease - therapy; Digestive System Surgical Procedures - methods; Female; Gene Expression Profiling - methods; Gene Expression Profiling - statistics & numerical data; Genome-Wide Association Study; Humans; Ileum - metabolism; Ileum - pathology; Ileum - surgery; Male; Original; Patient Selection; Pharmacogenomic Testing; Severity of Illness Index; Signal Transduction - genetics; United States; United States

Heterogeneity in Crohn's disease [CD] provides a challenge for the development of effective therapies. Our goal was to define a unique molecular signature for severe, refractory CD to enable precision therapy approaches to disease treatment and to facilitate earlier intervention in complicated...