Exploration of (R)-[11C]YH168 as a PET tracer for imaging monoacylglycerol lipase in the brain: from mice to non-human primates

• Published in: European journal of nuclear medicine and molecular imaging Vol. 52; no. 4; pp. 1556 - 1565
• Main Authors: He, Yingfang, Zheng, MingQiang, Gu, Jiwei, Reichert, Lisa, Trimborn, Johannes, Zhang, Hui, Keller, Claudia, Crosby, Mallory, Collin, Ludovic, Heer, Dominik, Pavlovic, Anto, Topp, Andreas, Wittwer, Matthias Beat, Grether, Uwe, Gobbi, Luca, Schibli, Roger, Huang, Yiyun, Mu, Linjing
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2025; Springer Nature B.V
• Subjects: Amygdala; Animals; Autoradiography; Binding; Boron; Brain; Brain - diagnostic imaging; Brain - enzymology; Brain - metabolism; Brain slice preparation; Carbon Radioisotopes; Cardiology; Central nervous system; Cerebellum; Chemical synthesis; Cortex (cingulate); Cortex (frontal); Cross coupling; Curve fitting; Endocannabinoid system; Globus pallidus; Hippocampus; Human performance; Imaging; Lipase; Macaca mulatta; Male; Medical imaging; Medicine; Medicine & Public Health; Methylation; Mice; Monkeys; Monoacylglycerol Lipases - antagonists & inhibitors; Monoacylglycerol Lipases - metabolism; Neuroimaging; Nuclear Medicine; Nucleus accumbens; Occipital lobe; Oncology; Original; Original Article; Orthopedics; Palladium; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; Primates; Putamen; Radioactive Tracers; Radioactivity; Radiology; Radiopharmaceuticals - pharmacokinetics; Substantia nigra; Temporal lobe; Thalamus; Therapeutic targets; Tissue Distribution; Neuroimaging; Monoacylglycerol lipase; Carbon-11; Drug development

Purpose The monoacylglycerol lipase (MAGL) plays a pivotal role in modulating the endocannabinoid system and is considered an attractive therapeutic target for diseases in both the central nervous system and periphery. The current study aimed to develop and evaluate a suitable carbon-11 labeled trac...