Exploration of (R)-[11C]YH168 as a PET tracer for imaging monoacylglycerol lipase in the brain: from mice to non-human primates - He, Yingfang; Zheng, MingQiang; Gu, Jiwei; Reichert, Lisa; Trimborn, Johannes; Zhang, Hui; Keller, Claudia; Crosby, Mallory; Collin, Ludovic; Heer, Dominik; Pavlovic, Anto; Topp, Andreas; et al. (European journal of nuclear medicine and molecular imaging, 2025)
Keywords: Amygdala; Animals; Autoradiography; Binding; Boron; Brain; Brain - diagnostic imaging; Brain - enzymology; Brain - metabolism; Brain slice preparation; Carbon Radioisotopes; Cardiology; Central nervous system; Cerebellum; Chemical synthesis; Cortex (cingulate); Cortex (frontal); Cross coupling; Curve fitting; Endocannabinoid system; Globus pallidus; Hippocampus; Human performance; Imaging; Lipase; Macaca mulatta; Male; Medical imaging; Medicine; Medicine & Public Health; Methylation; Mice; Monkeys; Monoacylglycerol Lipases - antagonists & inhibitors; Monoacylglycerol Lipases - metabolism; Neuroimaging; Nuclear Medicine; Nucleus accumbens; Occipital lobe; Oncology; Original; Original Article; Orthopedics; Palladium; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; Primates; Putamen; Radioactive Tracers; Radioactivity; Radiology; Radiopharmaceuticals - pharmacokinetics; Substantia nigra; Temporal lobe; Thalamus; Therapeutic targets; Tissue Distribution; Neuroimaging; Monoacylglycerol lipase; Carbon-11; Drug development