Bacteriophage Qβ virus-like particles displaying Chikungunya virus B-cell epitopes elicit high-titer E2 protein antibodies but fail to neutralize a Thailand strain of Chikungunya virus
•Immunization with 5 µg of CHIKV E2 peptide not displayed on VLPs is not immunogenic.•CHIKV E2 peptides can be displayed on bacteriophage VLPs.•Immunization with 5 µg of Qβ VLPs displaying E2 peptides is immunogenic.•Sera from bacteriophage VLPs-E2-immunized mice did not neutralize CHIKV. Chikunguny...
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Published in | Vaccine Vol. 38; no. 11; pp. 2542 - 2550 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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04.03.2020
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Abstract | •Immunization with 5 µg of CHIKV E2 peptide not displayed on VLPs is not immunogenic.•CHIKV E2 peptides can be displayed on bacteriophage VLPs.•Immunization with 5 µg of Qβ VLPs displaying E2 peptides is immunogenic.•Sera from bacteriophage VLPs-E2-immunized mice did not neutralize CHIKV.
Chikungunya virus (CHIKV) is a mosquito-borne virus associated with arthritis and musculoskeletal pains. More than 2.9 million people worldwide have been infected with the virus within the last 1.5 decades; currently, there are no approved vaccines to protect against CHIKV infection. To assess the potential of using CHIKV peptides as vaccine antigens, we multivalently displayed CHIKV peptides representing B-cell epitopes (amino acids 2800–2818, 3025–3058, 3073–3081, 3121–3146, and 3177–3210), from E2 glycoprotein (Singapore strain), on the surface of a highly immunogenic bacteriophage Qβ virus-like particle (VLP). We assessed the immunogenicity of CHIKV E2 amino acid 3025–3058 (including the other epitopes) displayed on Qβ VLPs in comparison to the same peptide not displayed on VLPs. Mice immunized with the E2 peptides displayed on Qβ VLPs elicited high-titer antibodies compared with the group immunized just with the peptide. However, sera from immunized mice did not neutralize CHIKV AF15561 (isolated from Thailand). The data suggest that Qβ VLPs is an excellent approach to elicit high-titer CHIKV E2-protein antibodies at a lower dose of antigen and future studies should assess whether Qβ-CHIKV E2 aa 2800–2818 VLPs and Qβ-CHIKV E2 aa 3025–3058 VLPs can neutralize a Singapore Strain of CHIKV. |
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AbstractList | Chikungunya virus (CHIKV) is a mosquito-borne virus associated with arthritis and musculoskeletal pains. More than 2.9 million people worldwide have been infected with the virus within the last 1.5 decades; currently, there are no approved vaccines to protect against CHIKV infection. To assess the potential of using CHIKV peptides as vaccine antigens, we multivalently displayed CHIKV peptides representing B-cell epitopes (amino acids 2800-2818, 3025-3058, 3073-3081, 3121-3146, and 3177-3210), from E2 glycoprotein (Singapore strain), on the surface of a highly immunogenic bacteriophage Qβ virus-like particle (VLP). We assessed the immunogenicity of CHIKV E2 amino acid 3025-3058 (including the other epitopes) displayed on Qβ VLPs in comparison to the same peptide not displayed on VLPs. Mice immunized with the E2 peptides displayed on Qβ VLPs elicited high-titer antibodies compared with the group immunized just with the peptide. However, sera from immunized mice did not neutralize CHIKV AF15561 (isolated from Thailand). The data suggest that Qβ VLPs is an excellent approach to elicit high-titer CHIKV E2-protein antibodies at a lower dose of antigen and future studies should assess whether Qβ-CHIKV E2 aa 2800-2818 VLPs and Qβ-CHIKV E2 aa 3025-3058 VLPs can neutralize a Singapore Strain of CHIKV. •Immunization with 5 µg of CHIKV E2 peptide not displayed on VLPs is not immunogenic.•CHIKV E2 peptides can be displayed on bacteriophage VLPs.•Immunization with 5 µg of Qβ VLPs displaying E2 peptides is immunogenic.•Sera from bacteriophage VLPs-E2-immunized mice did not neutralize CHIKV. Chikungunya virus (CHIKV) is a mosquito-borne virus associated with arthritis and musculoskeletal pains. More than 2.9 million people worldwide have been infected with the virus within the last 1.5 decades; currently, there are no approved vaccines to protect against CHIKV infection. To assess the potential of using CHIKV peptides as vaccine antigens, we multivalently displayed CHIKV peptides representing B-cell epitopes (amino acids 2800–2818, 3025–3058, 3073–3081, 3121–3146, and 3177–3210), from E2 glycoprotein (Singapore strain), on the surface of a highly immunogenic bacteriophage Qβ virus-like particle (VLP). We assessed the immunogenicity of CHIKV E2 amino acid 3025–3058 (including the other epitopes) displayed on Qβ VLPs in comparison to the same peptide not displayed on VLPs. Mice immunized with the E2 peptides displayed on Qβ VLPs elicited high-titer antibodies compared with the group immunized just with the peptide. However, sera from immunized mice did not neutralize CHIKV AF15561 (isolated from Thailand). The data suggest that Qβ VLPs is an excellent approach to elicit high-titer CHIKV E2-protein antibodies at a lower dose of antigen and future studies should assess whether Qβ-CHIKV E2 aa 2800–2818 VLPs and Qβ-CHIKV E2 aa 3025–3058 VLPs can neutralize a Singapore Strain of CHIKV. |
Author | Zhai, Lukai Rosso, Brenna Basu, Rupsa Tumban, Ebenezer |
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CitedBy_id | crossref_primary_10_3389_fbioe_2022_867119 crossref_primary_10_3390_ijms24098222 crossref_primary_10_3390_vaccines11020219 crossref_primary_10_1016_j_microb_2023_100018 crossref_primary_10_1021_acs_molpharmaceut_0c00828 crossref_primary_10_1021_acsomega_1c05975 crossref_primary_10_3389_fimmu_2020_00592 crossref_primary_10_2174_1573413719666230717123734 |
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Keywords | B-cell epitopes Vaccine FRNT Chikungunya virus Qβ virus-like particles (VLPs) Neutralization |
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Snippet | •Immunization with 5 µg of CHIKV E2 peptide not displayed on VLPs is not immunogenic.•CHIKV E2 peptides can be displayed on bacteriophage VLPs.•Immunization... Chikungunya virus (CHIKV) is a mosquito-borne virus associated with arthritis and musculoskeletal pains. More than 2.9 million people worldwide have been... |
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