Role of progestin-induced mammary-derived growth hormone in the pathogenesis of cystic endometrial hyperplasia in the bitch

• Published in: Domestic animal endocrinology Vol. 33; no. 3; pp. 294 - 312
• Main Authors: Bhatti, Sofie F.M., Rao, Nagesha A.S., Okkens, Auke C., Mol, Jan A., Duchateau, Luc, Ducatelle, Richard, van den Ingh, Ted S.G.A.M., Tshamala, Mulenda, Van Ham, Luc M.L., Coryn, Marc, Rijnberk, Ad, Kooistra, Hans S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2007
• Subjects: Animals; Dog; Dog Diseases - metabolism; Dog Diseases - pathology; Dogs; Endometrial Hyperplasia - metabolism; Endometrial Hyperplasia - pathology; Endometrial Hyperplasia - veterinary; endometrium; Female; Gene Expression; Growth Hormone - biosynthesis; Growth Hormone - blood; Growth Hormone - genetics; Growth Hormone - metabolism; growth hormone receptors; hormone receptors; hyperplasia; immunohistochemistry; Immunohistochemistry - veterinary; insulin-like growth factor I; Insulin-Like Growth Factor I - genetics; Insulin-Like Growth Factor I - metabolism; Mammary gland; mammary glands; Mammary Glands, Animal - metabolism; Mammary Glands, Animal - surgery; Mastectomy; medroxyprogesterone acetate; Medroxyprogesterone Acetate - pharmacology; pathogenesis; Progesterone; Progesterone - blood; progesterone receptors; Random Allocation; Receptors, Progesterone - genetics; Receptors, Progesterone - metabolism; Receptors, Somatotropin - genetics; Receptors, Somatotropin - metabolism; Reverse Transcriptase Polymerase Chain Reaction - veterinary; somatotropin; surgery; synthetic progestogens; Uterus; Uterus - metabolism; Uterus - pathology; Mastectomy; Mammary gland; Progesterone; Uterus; Dog

Endogenous progesterone and synthetic progestins may induce hypersecretion of growth hormone (GH) of mammary origin, hyperplastic ductular changes in the mammary gland, and the development of cystic endometrial hyperplasia (CEH) in dogs. It was investigated whether progestin-induced mammary GH plays...