Diagnostic efficacy of MnDPDP in MR imaging of the liver. A phase III multicentre study

• Published in: Acta radiologica (1987) Vol. 38; no. 4 Pt 2; p. 643
• Main Authors: Wang, C, Ahlström, H, Ekholm, S, Fagertun, H, Hellström, M, Hemmingsson, A, Holtås, S, Isberg, B, Jonnson, E, Lönnemark-Magnusson, M, McGill, S, Wallengren, N O, Westman, L
• Format: Journal Article
• Language: English
• Published: England 01.07.1997
• Subjects: Adult; Aged; Aged, 80 and over; Contrast Media - administration & dosage; Contrast Media - adverse effects; Edetic Acid - administration & dosage; Edetic Acid - adverse effects; Edetic Acid - analogs & derivatives; Female; Humans; Liver - pathology; Liver Neoplasms - diagnosis; Liver Neoplasms - secondary; Magnetic Resonance Imaging - instrumentation; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging - statistics & numerical data; Male; Manganese - administration & dosage; Manganese - adverse effects; Middle Aged; Pyridoxal Phosphate - administration & dosage; Pyridoxal Phosphate - adverse effects; Pyridoxal Phosphate - analogs & derivatives; Sweden; Sweden
• ISSN: 0284-1851; 1600-0455
• DOI: 10.1080/02841859709172395

To assess the diagnostic efficacy, safety and tolerability of mangafodipir trisodium (MnDPDP, Teslascan) in MR imaging of the liver. Eighty-two patients from 4 centres underwent MR imaging with pre-contrast sequences including T1-weighted SE and GRE, and T2-weighted turbo SE sequences. MnDPDP at a dose of 5 mumol/kg b.w. was administered by slow i.v. infusion, and 20-60 min after infusion the T1-weighted SE and GRE sequences were repeated. Diagnostic efficacy was evaluated by counting the number of lesions and by evaluating whether more information for lesion characterisation was available in post-contrast images. Safety and tolerability were assessed by recording adverse events and infusion-related discomfort. Significantly more lesions were found in MnDPDP-enhanced T1-weighted SE and GRE images than in unenhanced images of the same sequences. More lesions were also found in these images compared with T2-weighted images at a level of marginal significance. More information was obtained from MnDPDP-enhanced images in 40 cases. Mild to moderate adverse events were experienced by 17% of the patients. MnDPDP-enhanced images can improve lesion detection in the liver and are helpful for lesion characterisation. To obtain optimal diagnostic information of liver lesions T2-weighted images are also valuable. MnDPDP is a safe contrast agent for MR imaging of liver lesions.