Preparation and characterization of aligned porous PCL/zein scaffolds as drug delivery systems via improved unidirectional freeze-drying method

• Published in: Materials Science & Engineering C Vol. 68; pp. 613 - 622
• Main Authors: Fereshteh, Zeinab, Fathi, Mohammadhossein, Bagri, Akbar, Boccaccini, Aldo R.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2016
• Subjects: Aligned PCL/zein scaffolds; Controlled release; Delayed-Action Preparations - chemistry; Delayed-Action Preparations - pharmacokinetics; Drug delivery; Freeze Drying; Polyesters - chemistry; Protein release; Tetracycline - chemistry; Tetracycline - pharmacokinetics; Zein - chemistry; Aligned PCL/zein scaffolds; Drug delivery; Protein release; Freeze-drying; Controlled release

A novel type of drug-delivery scaffold based on poly(ε-caprolactone) (PCL) and zein blends was prepared by improved unidirectional freeze-drying. Scaffolds with tube-like pore structure and high porosity, up to 89%, were obtained by adjusting the concentration of the PCL and zein solutions. Characte...