Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis

• Published in: The Journal of immunology (1950) Vol. 199; no. 12; pp. 4066 - 4077
• Main Authors: Cui, Xiaotong, Mino, Takashi, Yoshinaga, Masanori, Nakatsuka, Yoshinari, Hia, Fabian, Yamasoba, Daichi, Tsujimura, Tohru, Tomonaga, Keizo, Suzuki, Yutaka, Uehata, Takuya, Takeuchi, Osamu
• Format: Journal Article
• Language: English
• Published: United States American Association of Immunologists 15.12.2017
• Subjects: Cell activation; Fibrosis; Furin; Heart diseases; Helper cells; Homeostasis; Inflammation; Interleukin 1; Interleukin 4; Lethality; Lymphocytes; Lymphocytes T; mRNA; Mutation; Polarization; RNA-binding protein; T cell receptors

Regnase-1 and Roquin are RNA binding proteins that are essential for degradation of inflammatory mRNAs and maintenance of immune homeostasis. Although deficiency of either of the proteins leads to enhanced T cell activation, their functional relationship in T cells has yet to be clarified because of...