Two Differently Regulated Nuclear Factor κ B Activation Pathways Triggered by the Cytoplasmic Tail of CD40

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 96; no. 4; pp. 1234 - 1239
• Main Authors: Tsukamoto, Nobuo, Kobayashi, Norihiko, Azuma, Sakura, Yamamoto, Tadashi, Inoue, Jun-ichiro
• Format: Journal Article
• Language: English
• Published: National Academy of Sciences of the United States of America 16.02.1999; National Acad Sciences; The National Academy of Sciences
• Subjects: Antibodies; B lymphocytes; Biochemistry; Biological Sciences; Cell extracts; Gels; Genetic mutation; Physiological regulation; Plasmids; Proteins; T lymphocytes

CD40 signaling modulates the immune response at least in part by activation of nuclear factor κ B (NFκ B). It has been shown that two distinct domains in the CD40 cytoplasmic tail (cyt), namely cyt-N and cyt-C, independently activate NFκ B. Although four members of the tumor necrosis factor receptor...