Elevated Expression of IL-33 and TSLP in the Airways of Human Asthmatics In Vivo: A Potential Biomarker of Severe Refractory Disease

• Published in: The Journal of immunology (1950) Vol. 200; no. 7; pp. 2253 - 2262
• Main Authors: Li, Yan, Wang, Wei, Lv, Zhe, Li, Yun, Chen, Yan, Huang, Kewu, Corrigan, Chris J, Ying, Sun
• Format: Journal Article
• Language: English
• Published: United States American Association of Immunologists 01.04.2018
• Subjects: Adrenal Cortex Hormones - therapeutic use; Alveoli; Asthma; Asthma - diagnosis; Asthma - drug therapy; Asthma - pathology; Biomarkers - metabolism; Bronchoalveolar Lavage Fluid - chemistry; Bronchoalveolar Lavage Fluid - cytology; Bronchus; Corticosteroids; Cytokines; Cytokines - metabolism; Eosinophils - cytology; Humans; Interleukin 12; Interleukin 13; Interleukin 2; Interleukin 4; Interleukin 5; Interleukin-33 - metabolism; Leukocyte Count; Leukocytes (eosinophilic); Leukocytes (neutrophilic); Lung - pathology; Lungs; Lymphocytes T; Neutrophils; Neutrophils - cytology; Pathogenesis; Respiratory function; Respiratory tract; Respiratory tract diseases; Th1 Cells - immunology; Th2 Cells - immunology; Thymic stromal lymphopoietin; Thymus; γ-Interferon

The epithelial cytokines IL-33, thymic stromal lymphopoietin (TSLP), and IL-25 have been implicated in asthma pathogenesis because they promote Th2-type cytokine synthesis, but their expression is relatively poorly documented in “real-life” human asthma. Using bronchoalveolar lavage fluid (BALF), we...