Usefulness of the INNOVANCE® PFA P2Y test cartridge for the detection of patients with congenital defects of the platelet P2Y12 receptor for adenosine diphosphate

• Published in: Thrombosis research Vol. 133; no. 2; pp. 254 - 256
• Main Authors: Scavone, Mariangela, Germanovich, Ksenia, Femia, Eti A., Cattaneo, Marco
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.02.2014
• Subjects: Adenosine Diphosphate - metabolism; Adolescent; Adult; Aged; Antiplatelet agents; Blood Platelets - metabolism; Female; Hematology, Oncology and Palliative Medicine; Humans; Male; Middle Aged; P2Y12 defect; P2Y12 purinoreceptor; PFA analyzer; PFA cartridges; Platelet function tests; Platelet Function Tests - instrumentation; Receptors, Purinergic P2Y12 - metabolism; Young Adult; VASP; CEPI; PRI; PFA; HS; Platelet function tests; PFA analyzer; ADP; P2Y12 defect; CT; CADP; P2Y12 purinoreceptor; PFA cartridges; Antiplatelet agents; platelet function analyzer; P2Y 12 purinoreceptor; healthy subjects; vasodilator-stimulated phosphoprotein; platelet reactivity index; collagen and epinephrine; closure time; P2Y 12 defect; adenosine diphosphate; collagen and ADP; P2Y purinoreceptor; P2Y defect

The platelet function analyzer (PFA)-100® is used in clinical practice to screen patients with bleeding diathesis and suspected defects of primary hemostasis. A new cartridge, INNOVANCE® PFA P2Y, has been specifically developed to monitor patients’ response to drugs inhibiting the platelet P2Y12 rec...