Near-infrared spectroscopic study and the Wada test for presurgical evaluation of expressive and receptive language functions in glioma patients: With a case report of dissociated language functions

• Published in: Neuroscience letters Vol. 510; no. 2; pp. 104 - 109
• Main Authors: Sato, Yosuke, Uzuka, Takeo, Aoki, Hiroshi, Natsumeda, Manabu, Oishi, Makoto, Fukuda, Masafumi, Fujii, Yukihiko
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 29.02.2012
• Subjects: Aged; Brain Mapping; Brain Neoplasms - physiopathology; Brain Neoplasms - surgery; Cerebrum - physiopathology; Dissociated language function; Female; Functional Laterality; Glioma; Glioma - physiopathology; Glioma - surgery; Humans; Language; Language Tests; Male; Middle Aged; Near-infrared spectroscopy; Preoperative Period; Spectroscopy, Near-Infrared; Speech Perception; Wada test; Wada test; Dissociated language function; Glioma; Near-infrared spectroscopy
• ISSN: 0304-3940; 1872-7972; 1872-7972
• DOI: 10.1016/j.neulet.2012.01.011

► NIRS can evaluate the expressive and receptive language functions separately. ► The results were completely consistent with those of the Wada test. ► NIRS detected the dissociated language pattern in a glioma patient. ► This pattern was validated by the Wada test and the postoperative neurological course. ► Our NIRS study provides extremely important information for presurgical planning. Near-infrared spectroscopy (NIRS) has proven to be useful for the evaluation of language lateralization in healthy subjects, infants, and epileptic patients. This study for the first time investigated the expressive and receptive language functions separately, using NIRS in presurgical glioma patients. We also describe a special case with dissociated pattern of language functions. Ten glioma patients were examined. Using NIRS, the hemodynamic changes during a verb generation task or story listening task were measured in the cerebral hemisphere on either side covering the language areas. Following the NIRS study, the Wada test was performed in all the patients. The NIRS study revealed increases of oxyhemoglobin and decreases of deoxyhemoglobin in the language areas elicited by both tasks. In 9 patients, who were all right-handed, the expressive and receptive language functions were lateralized to the left hemisphere. The results of the NIRS study were completely consistent with those of the Wada test. In the remaining 1 patient with a right sided insular glioma, who was right-handed, the NIRS study revealed stronger activation of the right inferior frontal region during the verb generation task, and stronger activation of the left superior temporal region during the story listening task. This dissociated language function was validated by the Wada test and the postoperative neurological course. These results demonstrate that a NIRS study using our technique is extremely valuable for preoperative assessment of the language functions and exemplifies how a preoperative NIRS study can allow detection of unforeseen language lateralization.