Vitamin B-6 Deficiency in Germfree Rats

• Published in: The Journal of nutrition Vol. 107; no. 9; pp. 1707 - 1714
• Main Authors: Sumi, Yukiko, Miyakawa, Masasumi, Kanzaki, Masanori, Kotake, Yahito
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.1977
• Subjects: Animals; Cerebellum - metabolism; Diaphragm - pathology; Germ-Free Life; germfree animal; Intestines - microbiology; Liver - metabolism; Lung - pathology; Male; microflora; Pulmonary Atelectasis - etiology; Pulmonary Atelectasis - pathology; Pyridoxine - metabolism; Pyridoxine - therapeutic use; pyridoxine deficiency; Ranvier's Nodes - pathology; Rats; Vitamin B 6 Deficiency - complications; Vitamin B 6 Deficiency - drug therapy; Vitamin B 6 Deficiency - microbiology; Vitamin B 6 Deficiency - pathology; Xanthurenates - urine; germfree animal; pyridoxine deficiency; microflora

Germfree and conventional rats were used to investigate the influence of gut microflora upon vitamin B-6 deficiency. The body weights of conventional rats fed a vitamin B-6-deficient diet for more than 5 weeks plateaued, but the rats remained alive until the end of week 9 of deficiency. The body wei...