Anti- Pseudomonas aeruginosa xanthones from the resin and green fruits of Cratoxylum cochinchinense

Cochinchinones I–L ( 1– 3 and 13) along with 11 known xanthones ( 4– 12, 14, and 15) were isolated from the resin and green fruits of Cratoxylum cochinchinense. In addition, four new acetylated compounds ( 16– 19) were derivatized from 7-geranyloxy-1,3-dihydroxyxanthone ( 14) and 3-geranyloxy-1,7-di...

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Published inTetrahedron Vol. 65; no. 15; pp. 3003 - 3013
Main Authors Boonnak, Nawong, Karalai, Chatchanok, Chantrapromma, Suchada, Ponglimanont, Chanita, Fun, Hoong-Kun, Kanjana-Opas, Akkharawit, Chantrapromma, Kan, Kato, Shigeru
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LanguageEnglish
Published OXFORD Elsevier Ltd 11.04.2009
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Abstract Cochinchinones I–L ( 1– 3 and 13) along with 11 known xanthones ( 4– 12, 14, and 15) were isolated from the resin and green fruits of Cratoxylum cochinchinense. In addition, four new acetylated compounds ( 16– 19) were derivatized from 7-geranyloxy-1,3-dihydroxyxanthone ( 14) and 3-geranyloxy-1,7-dihydroxyxanthone ( 15). All compounds were characterized on the basis of spectroscopic analyses. The structures of cochinchinone I ( 1), a monoacetate ( 18) and a dibrosylate ( 20), were also confirmed by X-ray diffraction analysis. The antibacterial and antifungal activities of selected compounds were evaluated as well. Cochinchinones I–L ( 1– 3 and 13) along with 11 known xanthones ( 4– 12, 14, and 15) were isolated from the resin and green fruits of Cratoxylum cochinchinense. In addition, four new acetylated compounds ( 16– 19) were derivatized from 7-geranyloxy-1,3-dihydroxyxanthone ( 14) and 3-geranyloxy-1,7-dihydroxyxanthone ( 15). All compounds were characterized on the basis of spectroscopic analyses. The structures of cochinchinone I ( 1), a monoacetate ( 18) and a dibrosylate ( 20), were also confirmed by X-ray diffraction analysis. The antibacterial and antifungal activities of selected compounds were evaluated as well. [Display omitted]
AbstractList Cochinchinones I–L ( 1– 3 and 13) along with 11 known xanthones ( 4– 12, 14, and 15) were isolated from the resin and green fruits of Cratoxylum cochinchinense. In addition, four new acetylated compounds ( 16– 19) were derivatized from 7-geranyloxy-1,3-dihydroxyxanthone ( 14) and 3-geranyloxy-1,7-dihydroxyxanthone ( 15). All compounds were characterized on the basis of spectroscopic analyses. The structures of cochinchinone I ( 1), a monoacetate ( 18) and a dibrosylate ( 20), were also confirmed by X-ray diffraction analysis. The antibacterial and antifungal activities of selected compounds were evaluated as well. Cochinchinones I–L ( 1– 3 and 13) along with 11 known xanthones ( 4– 12, 14, and 15) were isolated from the resin and green fruits of Cratoxylum cochinchinense. In addition, four new acetylated compounds ( 16– 19) were derivatized from 7-geranyloxy-1,3-dihydroxyxanthone ( 14) and 3-geranyloxy-1,7-dihydroxyxanthone ( 15). All compounds were characterized on the basis of spectroscopic analyses. The structures of cochinchinone I ( 1), a monoacetate ( 18) and a dibrosylate ( 20), were also confirmed by X-ray diffraction analysis. The antibacterial and antifungal activities of selected compounds were evaluated as well. [Display omitted]
Cochinchinones 1-L (1-3 and 13) along with 11 known xanthones (4-12,14, and 15) were isolated from the resin and green fruits of Cratoxylum cochinchinense. In addition, four new acetylated compounds (1619) were derivatized from 7-geranyloxy-1,3-dihydroxyxanthone (14) and 3-geranyloxy-1,7-dihydroxyxanthone (15). All compounds were characterized on the basis of spectroscopic analyses. The structures of cochinchinone I (1), a monoacetate (18) and a dibrosylate (20), were also confirmed by X-ray diffraction analysis. The antibacterial and antifungal activities of selected Compounds were evaluated as well. (C) 2009 Elsevier Ltd. All rights reserved.
Author Ponglimanont, Chanita
Fun, Hoong-Kun
Boonnak, Nawong
Chantrapromma, Kan
Kanjana-Opas, Akkharawit
Kato, Shigeru
Karalai, Chatchanok
Chantrapromma, Suchada
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Issue 15
Keywords Cratoxylum cochinchinense
Antifungal activity
Antibacterial activity
Pseudomonas aeruginosa
1,3,7-Trioxygenated xanthone
1,3,7-Trihydroxyxanthone
PRENYLATED XANTHONES
BACTERIAL
DERIVATIVES
Pseudomonadales
Xanthone
Fruit
Natural resin
Molecular structure
X ray diffraction
Characterization
Antifungal agent
Bacteria
Pseudomonadaceae
Isolation
Antibacterial agent
Spectrophotometry
Language English
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Snippet Cochinchinones I–L ( 1– 3 and 13) along with 11 known xanthones ( 4– 12, 14, and 15) were isolated from the resin and green fruits of Cratoxylum...
Cochinchinones 1-L (1-3 and 13) along with 11 known xanthones (4-12,14, and 15) were isolated from the resin and green fruits of Cratoxylum cochinchinense. In...
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SubjectTerms 1,3,7-Trihydroxyxanthone
1,3,7-Trioxygenated xanthone
Antibacterial activity
Antifungal activity
Biological and medical sciences
Chemistry
Chemistry, Organic
Cratoxylum cochinchinense
General pharmacology
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Physical Sciences
Pseudomonas aeruginosa
Science & Technology
Title Anti- Pseudomonas aeruginosa xanthones from the resin and green fruits of Cratoxylum cochinchinense
URI https://dx.doi.org/10.1016/j.tet.2009.01.083
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