Induction of mammary cancer and lymphoma by multiple, low oral doses of 7,12-dimethylbenz[a]anthracene in SENCAR mice

• Published in: Carcinogenesis (New York) Vol. 18; no. 3; pp. 553 - 559
• Main Authors: QING, W.-G, CONTI, C. J, LABATE, M, JOHNSTON, D, SLAGA, T. J, MACLEOD, M. C
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.03.1997
• Subjects: 9,10-Dimethyl-1,2-benzanthracene - administration & dosage; Adenocarcinoma - chemically induced; Adenocarcinoma - genetics; Administration, Oral; Animal tumors. Experimental tumors; Animals; Biological and medical sciences; Carcinogens - administration & dosage; Codon - genetics; DNA Mutational Analysis; DNA, Neoplasm - genetics; Dose-Response Relationship, Drug; Experimental genital and mammary tumors; Female; Genes, ras - drug effects; Lymphoma - chemically induced; Lymphoma - genetics; Mammary Neoplasms, Experimental - chemically induced; Mammary Neoplasms, Experimental - genetics; Medical sciences; Mice; Mice, Inbred SENCAR; Organ Specificity; Point Mutation; Polymerase Chain Reaction; Tumors; Immunopathology; Animal model; Pathogenesis; Low dose; Rodentia; Oral administration; Administration schedule; Malignant hemopathy; Malignant tumor; Carcinogenesis; Lymphoma; Multiple dose; Mammary gland diseases; Carcinogen; Vertebrata; Mammalia; Mouse; Lymphoproliferative syndrome; Mammary gland; High dose

Existing models of mouse mammary carcinogenesis induced by the model polycyclic aromatic hydrocarbon 7,12-dimethylbenz[a]anthracene (DMBA) typically use a small number of bolus doses applied intragastrically. In contrast to this, typical human exposures to carcinogens are thought to be at lower dose...