Anti-nucleosome and anti-chromatin antibodies are present in active systemic lupus erythematosus but not in the cutaneous form of the disease

• Published in: Lupus Vol. 18; no. 3; pp. 223 - 229
• Main Authors: Souza, A, da Silva, LM, Oliveira, FR, Roselino, AMF, Louzada-Junior, P
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.03.2009; Sage Publications Ltd
• Subjects: Adolescent; Adult; Aged; Antibodies; Antibodies, Antinuclear - immunology; Antigens; Autoantibodies - immunology; Child; Chromatin - immunology; Enzymes; Female; Humans; Lupus; Lupus Erythematosus, Cutaneous - immunology; Lupus Erythematosus, Cutaneous - physiopathology; Lupus Erythematosus, Systemic - immunology; Lupus Erythematosus, Systemic - physiopathology; Male; Middle Aged; Nucleosomes - immunology; Severity of Illness Index; Statistical analysis; Thymus gland; Young Adult; Brazil; United States > US; California; SLEDAI; anti-chromatin; systemic lupus erythematosus; anti-nucleosome; cutaneous lupus

The objective of this study is to investigate the presence of anti-nucleosome (anti-NCS) and anti-chromatin (anti-CRT) antibodies in patients with cutaneous lupus erythematosus (CLE) compared with active and inactive systemic lupus erythematosus (SLE). A total of 154 subjects were evaluated: 54 pati...