Genetics and pharmacogenetics of estrogen response

Estrogens are a steroid hormone group distributed widely in animals and human beings. Estrogens diffuse across cell phospholipidic membranes and interact with estrogen receptors. Their highest concentration is found in target tissues with reproductive function (breast, ovary, vagina and uterus). Hig...

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Published inExpert Review of Endocrinology & Metabolism Vol. 2; no. 4; pp. 503 - 516
Main Authors Carbonell Sala, Silvia, Martineti, Valentina, Carossino, Anna Maria, Brandi, Maria Luisa
Format Journal Article Book Review
LanguageEnglish
Published London Taylor & Francis 01.07.2007
Expert Reviews Ltd
Informa Healthcare
Subjects
Anopheles
Cancer
Care and treatment
Colorectal cancer
Estrogen
estrogen isoforms
estrogen receptor
estrogen response
estrogen-related disease
Genetic aspects
Genetics
Nervous system diseases
Osteoporosis
Pharmacogenetics
Phenols
polymorphism
Tumors
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Summary:Estrogens are a steroid hormone group distributed widely in animals and human beings. Estrogens diffuse across cell phospholipidic membranes and interact with estrogen receptors. Their highest concentration is found in target tissues with reproductive function (breast, ovary, vagina and uterus). High estrogen levels are usually associated with tumor onset and progression, while loss of estrogen or its receptor(s) contributes to development and/or progression of various diseases (osteoporosis, neurodegenerative disease and cardiovascular disease). Despite the numerous efforts to highlight estrogen's mechanism of action, recent discoveries showed an unexpected degree of complexity of estrogenic response.
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ISSN:1744-6651
1744-8417
DOI:10.1586/17446651.2.4.503