Single-cell transcriptional logic of cell-fate specification and axon guidance in early-born retinal neurons

Retinal ganglion cells (RGCs), cone photoreceptors (cones), horizontal cells and amacrine cells are the first classes of neurons produced in the retina. However, an important question is how this diversity of cell states is transcriptionally produced. Here, we profiled 6067 single retinal cells to p...

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Published inDevelopment (Cambridge) Vol. 146; no. 17
Main Authors Lo Giudice, Quentin, Leleu, Marion, La Manno, Gioele, Fabre, Pierre J
Format Journal Article
LanguageEnglish
Published England 09.09.2019
Subjects
Cell-fate specification
Mouse
Single-cell RNA-seq
Retinal development
Axon guidance
Neurogenesis
Retinal ganglion cell
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Abstract Retinal ganglion cells (RGCs), cone photoreceptors (cones), horizontal cells and amacrine cells are the first classes of neurons produced in the retina. However, an important question is how this diversity of cell states is transcriptionally produced. Here, we profiled 6067 single retinal cells to provide a comprehensive transcriptomic atlas showing the diversity of the early developing mouse retina. RNA velocities unveiled the dynamics of cell cycle coordination of early retinogenesis and define the transcriptional sequences at work during the hierarchical production of early cell-fate specification. We show that RGC maturation follows six waves of gene expression, with older-generated RGCs transcribing increasing amounts of guidance cues for young peripheral RGC axons that express the matching receptors. Spatial transcriptionally deduced features in subpopulations of RGCs allowed us to define novel molecular markers that are spatially restricted. Finally, the isolation of such a spatially restricted population, ipsilateral RGCs, allowed us to identify their molecular identity at the time they execute axon guidance decisions. Together, these data represent a valuable resource shedding light on transcription factor sequences and guidance cue dynamics during mouse retinal development.
AbstractList Retinal ganglion cells (RGC), cone photoreceptors (cones), horizontal cells (HC) and amacrine cells (AC) are the first classes of neurons produced in the retina. However, an important question is how this diversity of cell states is transcriptionally produced. Here we profiled 6,067 single retinal cells to provide a comprehensive transcriptomic atlas showing the diversity of the early developing mouse retina. RNA velocities unveiled dynamics of cell-cycle coordination of early retinogenesis and define the transcriptional sequences at work during the hierarchical production of early cell-fate specification. We show that RGC maturation follows six waves of gene expression, with older-generated RGCs transcribing increasing amount of guidance cues for young peripheral RGC axons that express the matching receptors. Spatial transcriptionally-deduced features in sub-populations of RGCs allowed us to define novel molecular markers that are spatially restricted. Finally, the isolation of such a spatially restricted population, ipsilateral RGCs, allowed us to identify their molecular identity at the time they execute axon guidance decisions. Together, these data represent a valuable resource shedding light on transcription factor sequences and guidance cue dynamics during mouse retinal development.
Retinal ganglion cells (RGCs), cone photoreceptors (cones), horizontal cells and amacrine cells are the first classes of neurons produced in the retina. However, an important question is how this diversity of cell states is transcriptionally produced. Here, we profiled 6067 single retinal cells to provide a comprehensive transcriptomic atlas showing the diversity of the early developing mouse retina. RNA velocities unveiled the dynamics of cell cycle coordination of early retinogenesis and define the transcriptional sequences at work during the hierarchical production of early cell-fate specification. We show that RGC maturation follows six waves of gene expression, with older-generated RGCs transcribing increasing amounts of guidance cues for young peripheral RGC axons that express the matching receptors. Spatial transcriptionally deduced features in subpopulations of RGCs allowed us to define novel molecular markers that are spatially restricted. Finally, the isolation of such a spatially restricted population, ipsilateral RGCs, allowed us to identify their molecular identity at the time they execute axon guidance decisions. Together, these data represent a valuable resource shedding light on transcription factor sequences and guidance cue dynamics during mouse retinal development.
Author Lo Giudice, Quentin
La Manno, Gioele
Fabre, Pierre J
Leleu, Marion
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  fullname: Leleu, Marion
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  givenname: Pierre J
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  surname: Fabre
  fullname: Fabre, Pierre J
  email: pierre.fabre@unige.ch
  organization: Department of Basic Neurosciences, University of Geneva, 1205 Geneva, Switzerland pierre.fabre@unige.ch
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Cites_doi 10.1038/nmeth.4150
10.1016/S0896-6273(00)80373-6
10.1074/jbc.M112.340174
10.1002/cne.23635
10.1016/j.stem.2018.04.014
10.1146/annurev.neuro.28.061604.135714
10.1186/1471-213X-6-62
10.1016/j.conb.2014.02.014
10.1002/cne.24467
10.1146/annurev-neuro-071714-033842
10.1523/JNEUROSCI.09-12-04179.1989
10.1126/science.aaa1934
10.1083/jcb.200509098
10.1073/pnas.1002530107
10.1038/s41467-018-05134-3
10.1098/rspb.1985.0021
10.1016/j.jneumeth.2004.09.020
10.1016/j.neuron.2008.01.006
10.1038/sj.onc.1205888
10.1242/dev.00724
10.1523/ENEURO.0169-16.2016
10.1038/emboj.2010.172
10.1146/annurev-neuro-071714-034120
10.1523/JNEUROSCI.0394-11.2011
10.1016/j.ydbio.2009.09.034
10.1016/j.neuron.2014.12.052
10.1038/328131a0
10.1038/s41586-018-0414-6
10.1016/j.cell.2004.10.026
10.1073/pnas.1203138109
10.7554/eLife.13374
10.1126/science.aad8361
10.1186/s13073-018-0567-9
10.1186/1471-213X-7-78
10.1038/35053522
10.1038/nn.4366
10.1371/journal.pone.0001588
10.1038/nbt.4096
10.1016/0012-1606(89)90146-2
10.1016/j.ydbio.2006.06.017
10.1016/j.cub.2019.02.052
10.1073/pnas.0705465104
10.1523/JNEUROSCI.2478-08.2008
10.1016/j.ymthe.2016.12.015
10.1038/nmeth.4402
10.1523/JNEUROSCI.20-13-04975.2000
10.1016/j.celrep.2017.01.075
10.1093/nar/gkn923
10.1073/pnas.0903264106
10.1016/S0092-8674(03)00684-6
10.1016/j.tins.2012.05.004
10.1038/s41598-018-20463-5
10.1002/dneu.22261
10.1523/JNEUROSCI.0564-11.2011
10.1016/0896-6273(90)90136-4
10.1016/j.conb.2016.11.010
10.1016/j.neuron.2003.08.017
10.1016/j.cell.2012.11.049
10.1523/JNEUROSCI.5655-08.2009
10.1167/iovs.17-22442
10.7554/eLife.25946
10.1002/cne.20134
10.1523/JNEUROSCI.15-07-04727.1995
10.1016/S0896-6273(03)00756-6
10.1101/sqb.2015.80.027177
10.1016/j.devcel.2014.07.015
10.1016/j.celrep.2016.11.016
10.1016/j.devcel.2016.11.020
10.1523/JNEUROSCI.4708-12.2013
10.1016/S0896-6273(00)80414-6
10.1126/science.aad2456
10.1073/pnas.0831080100
10.1146/annurev.neuro.31.060407.125609
10.1126/science.2449732
10.1038/nn919
10.1371/journal.pbio.0050241
10.1242/dev.126.3.555
10.1242/dev.01431
10.1016/j.neuron.2017.12.028
10.1523/JNEUROSCI.3778-09.2010
10.1140/epjb/e2013-40829-0
10.1126/science.1260384
10.1016/j.devcel.2013.06.005
10.1016/0092-8674(90)90297-R
10.1242/dev.119.1.49
10.1242/dev.108.3.515
10.1016/j.neuron.2019.04.010
10.1088/1742-5468/2008/10/P10008
10.1038/nrn3767
10.1038/nprot.2008.211
10.21105/joss.00861
10.1136/jmg.40.8.616
10.1016/j.cell.2018.06.021
10.1186/s12915-018-0570-z
10.1038/nn.4216
10.1016/j.cell.2016.07.054
10.1016/j.cell.2015.05.002
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Issue 17
Keywords Cell-fate specification
Mouse
Single-cell RNA-seq
Retinal development
Axon guidance
Neurogenesis
Retinal ganglion cell
Language English
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References Takahashi (2021042622511838200_DEV178103C77) 2003; 130
Hirata (2021042622511838200_DEV178103C37) 1993; 119
Mattar (2021042622511838200_DEV178103C51) 2015; 85
Corbo (2021042622511838200_DEV178103C16) 2007; 104
Emerson (2021042622511838200_DEV178103C22) 2013; 26
Seabrook (2021042622511838200_DEV178103C73) 2017; 40
Morin (2021042622511838200_DEV178103C55) 2014; 522
Herrera (2021042622511838200_DEV178103C35) 2003; 114
Thompson (2021042622511838200_DEV178103C81) 2009; 335
Hameed (2021042622511838200_DEV178103C32) 2003; 40
Qiu (2021042622511838200_DEV178103C66) 2017; 14
Marcucci (2021042622511838200_DEV178103C48) 2016; 17
Shewan (2021042622511838200_DEV178103C75) 2002; 5
Guo (2021042622511838200_DEV178103C99) 2018; 8
Livesey (2021042622511838200_DEV178103C46) 2001; 2
Hanchate (2021042622511838200_DEV178103C33) 2015; 350
Herrera (2021042622511838200_DEV178103C36) 2004; 131
Decembrini (2021042622511838200_DEV178103C17) 2017; 25
Butler (2021042622511838200_DEV178103C6) 2018; 36
Guillery (2021042622511838200_DEV178103C30) 1995; 15
Shekhar (2021042622511838200_DEV178103C74) 2016; 166
Murcia-Belmonte (2021042622511838200_DEV178103C56) 2019; 29
Bélanger (2021042622511838200_DEV178103C3) 2017; 40
Erskine (2021042622511838200_DEV178103C23) 2000; 20
Chinchore (2021042622511838200_DEV178103C13) 2017; 6
Turner (2021042622511838200_DEV178103C84) 1990; 4
Deiner (2021042622511838200_DEV178103C18) 1997; 19
La Manno (2021042622511838200_DEV178103C44) 2018; 560
Zhuang (2021042622511838200_DEV178103C97) 2005; 143
Rossi (2021042622511838200_DEV178103C71) 2017; 42
Kester (2021042622511838200_DEV178103C42) 2018; 23
Wetts (2021042622511838200_DEV178103C88) 1988; 239
Young (2021042622511838200_DEV178103C92) 2013; 33
Díaz (2021042622511838200_DEV178103C19) 2003; 100
el-Ghissassi (2021042622511838200_DEV178103C21) 2002; 21
van der Maaten (2021042622511838200_DEV178103C85) 2014; 15
Leamey (2021042622511838200_DEV178103C45) 2007; 5
Gore (2021042622511838200_DEV178103C28) 2008; 57
Sanes (2021042622511838200_DEV178103C72) 2015; 38
Petros (2021042622511838200_DEV178103C61) 2009; 29
Wang (2021042622511838200_DEV178103C87) 2016; 3
Huang (2021042622511838200_DEV178103C38) 2008; 4
Qiu (2021042622511838200_DEV178103C65) 2017; 14
Pak (2021042622511838200_DEV178103C57) 2004; 119
Wetts (2021042622511838200_DEV178103C89) 1989; 136
Cepko (2021042622511838200_DEV178103C10) 2014; 15
Macosko (2021042622511838200_DEV178103C47) 2015; 161
Kohwi (2021042622511838200_DEV178103C43) 2013; 152
Tasic (2021042622511838200_DEV178103C78) 2016; 19
Poulin (2021042622511838200_DEV178103C63) 2016; 19
Boije (2021042622511838200_DEV178103C5) 2014; 27
Cherry (2021042622511838200_DEV178103C12) 2009; 106
Iida (2021042622511838200_DEV178103C40) 2015; 75
Williams (2021042622511838200_DEV178103C91) 2003; 39
Zheng (2021042622511838200_DEV178103C96) 2016; 5
Hafler (2021042622511838200_DEV178103C31) 2012; 109
Bassett (2021042622511838200_DEV178103C1) 2012; 35
Drager (2021042622511838200_DEV178103C20) 1985; 224
Martersteck (2021042622511838200_DEV178103C50) 2017; 18
Reh (2021042622511838200_DEV178103C68) 1989; 9
Rheaume (2021042622511838200_DEV178103C69) 2018; 9
Yuan (2021042622511838200_DEV178103C93) 2018; 10
Hayashi (2021042622511838200_DEV178103C34) 2014; 30
Petros (2021042622511838200_DEV178103C60) 2008; 31
Thompson (2021042622511838200_DEV178103C80) 2006; 296
Ming (2021042622511838200_DEV178103C54) 1997; 19
Rivlin-Etzion (2021042622511838200_DEV178103C70) 2011; 31
Cayouette (2021042622511838200_DEV178103C9) 2003; 40
Fabre (2021042622511838200_DEV178103C24) 2010; 30
Pereira (2021042622511838200_DEV178103C59) 2010; 107
Fabre (2021042622511838200_DEV178103C26) 2018; 16
Fabre (2021042622511838200_DEV178103C25) 2015; 80
Huang (2021042622511838200_DEV178103C39) 2009; 37
Purohit (2021042622511838200_DEV178103C64) 2012; 287
Rapaport (2021042622511838200_DEV178103C67) 2004; 474
Chen (2021042622511838200_DEV178103C11) 2007; 7
Belliveau (2021042622511838200_DEV178103C4) 1999; 126
García-Frigola (2021042622511838200_DEV178103C27) 2010; 29
Turner (2021042622511838200_DEV178103C83) 1987; 328
Cang (2021042622511838200_DEV178103C7) 2008; 28
Marcucci (2021042622511838200_DEV178103C49) 2019; 527
Ozertem (2021042622511838200_DEV178103C100) 2011; 12
Poggi (2021042622511838200_DEV178103C62) 2005; 171
McInnes (2021042622511838200_DEV178103C52) 2018; 3
Peng (2021042622511838200_DEV178103C58) 2018; 97
Telley (2021042622511838200_DEV178103C79) 2016; 351
Behesti (2021042622511838200_DEV178103C2) 2006; 6
McLaughlin (2021042622511838200_DEV178103C53) 2005; 28
Trimarchi (2021042622511838200_DEV178103C82) 2008; 3
Carreres (2021042622511838200_DEV178103C8) 2011; 31
Waltman (2021042622511838200_DEV178103C86) 2013; 86
Zeisel (2021042622511838200_DEV178103C95) 2018; 174
Clark (2021042622511838200_DEV178103C14) 2019; 102
Zeisel (2021042622511838200_DEV178103C94) 2015; 347
Groman-Lupa (2021042622511838200_DEV178103C29) 2017; 58
Colello (2021042622511838200_DEV178103C15) 1990; 108
Katajisto (2021042622511838200_DEV178103C41) 2015; 348
Blondel (2021042622511838200_DEV178103C98) 2008; 2008
Williams (2021042622511838200_DEV178103C90) 1990; 63
References_xml – volume: 14
  start-page: 309
  year: 2017
  ident: 2021042622511838200_DEV178103C65
  article-title: Single-cell mRNA quantification and differential analysis with Census
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.4150
  contributor:
    fullname: Qiu
– volume: 19
  start-page: 575
  year: 1997
  ident: 2021042622511838200_DEV178103C18
  article-title: Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia
  publication-title: Neuron
  doi: 10.1016/S0896-6273(00)80373-6
  contributor:
    fullname: Deiner
– volume: 287
  start-page: 27126
  year: 2012
  ident: 2021042622511838200_DEV178103C64
  article-title: Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.340174
  contributor:
    fullname: Purohit
– volume: 522
  start-page: 3733
  year: 2014
  ident: 2021042622511838200_DEV178103C55
  article-title: Retinofugal projections in the mouse
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.23635
  contributor:
    fullname: Morin
– volume: 23
  start-page: 166
  year: 2018
  ident: 2021042622511838200_DEV178103C42
  article-title: Single-cell transcriptomics meets lineage tracing
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2018.04.014
  contributor:
    fullname: Kester
– volume: 28
  start-page: 327
  year: 2005
  ident: 2021042622511838200_DEV178103C53
  article-title: Molecular gradients and development of retinotopic maps
  publication-title: Annu. Rev. Neurosci.
  doi: 10.1146/annurev.neuro.28.061604.135714
  contributor:
    fullname: McLaughlin
– volume: 6
  start-page: 62
  year: 2006
  ident: 2021042622511838200_DEV178103C2
  article-title: The level of BMP4 signaling is critical for the regulation of distinct T-box gene expression domains and growth along the dorso-ventral axis of the optic cup
  publication-title: BMC Dev. Biol.
  doi: 10.1186/1471-213X-6-62
  contributor:
    fullname: Behesti
– volume: 27
  start-page: 68
  year: 2014
  ident: 2021042622511838200_DEV178103C5
  article-title: Reconciling competence and transcriptional hierarchies with stochasticity in retinal lineages
  publication-title: Curr. Opin. Neurobiol.
  doi: 10.1016/j.conb.2014.02.014
  contributor:
    fullname: Boije
– volume: 527
  start-page: 212
  year: 2019
  ident: 2021042622511838200_DEV178103C49
  article-title: Distinct timing of neurogenesis of ipsilateral and contralateral retinal ganglion cells
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.24467
  contributor:
    fullname: Marcucci
– volume: 40
  start-page: 499
  year: 2017
  ident: 2021042622511838200_DEV178103C73
  article-title: Architecture, function, and assembly of the mouse visual system
  publication-title: Annu. Rev. Neurosci.
  doi: 10.1146/annurev-neuro-071714-033842
  contributor:
    fullname: Seabrook
– volume: 12
  start-page: 1249
  year: 2011
  ident: 2021042622511838200_DEV178103C100
  article-title: Locally defined principal curves and surfaces
  publication-title: J. Machine Learning Res.
  contributor:
    fullname: Ozertem
– volume: 9
  start-page: 4179
  year: 1989
  ident: 2021042622511838200_DEV178103C68
  article-title: Age of differentiation determines rat retinal germinal cell phenotype: induction of differentiation by dissociation
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.09-12-04179.1989
  contributor:
    fullname: Reh
– volume: 347
  start-page: 1138
  year: 2015
  ident: 2021042622511838200_DEV178103C94
  article-title: Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
  publication-title: Science
  doi: 10.1126/science.aaa1934
  contributor:
    fullname: Zeisel
– volume: 15
  start-page: 3221
  year: 2014
  ident: 2021042622511838200_DEV178103C85
  article-title: Accelerating t-SNE using tree-based algorithms
  publication-title: J. Mach. Learn. Res.
  contributor:
    fullname: van der Maaten
– volume: 171
  start-page: 991
  year: 2005
  ident: 2021042622511838200_DEV178103C62
  article-title: Influences on neural lineage and mode of division in the zebrafish retina in vivo
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200509098
  contributor:
    fullname: Poggi
– volume: 107
  start-page: 15957
  year: 2010
  ident: 2021042622511838200_DEV178103C59
  article-title: Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1002530107
  contributor:
    fullname: Pereira
– volume: 9
  start-page: 2759
  year: 2018
  ident: 2021042622511838200_DEV178103C69
  article-title: Single cell transcriptome profiling of retinal ganglion cells identifies cellular subtypes
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-05134-3
  contributor:
    fullname: Rheaume
– volume: 224
  start-page: 57
  year: 1985
  ident: 2021042622511838200_DEV178103C20
  article-title: Birth dates of retinal ganglion cells giving rise to the crossed and uncrossed optic projections in the mouse
  publication-title: Proc. R. Soc. Lond. Biol. Sci.
  doi: 10.1098/rspb.1985.0021
  contributor:
    fullname: Drager
– volume: 143
  start-page: 27
  year: 2005
  ident: 2021042622511838200_DEV178103C97
  article-title: Targeted gene expression in dopamine and serotonin neurons of the mouse brain
  publication-title: J. Neurosci. Methods
  doi: 10.1016/j.jneumeth.2004.09.020
  contributor:
    fullname: Zhuang
– volume: 57
  start-page: 501
  year: 2008
  ident: 2021042622511838200_DEV178103C28
  article-title: Stem cell factor functions as an outgrowth-promoting factor to enable axon exit from the midline intermediate target
  publication-title: Neuron
  doi: 10.1016/j.neuron.2008.01.006
  contributor:
    fullname: Gore
– volume: 21
  start-page: 6772
  year: 2002
  ident: 2021042622511838200_DEV178103C21
  article-title: BTG2TIS21/PC3 induces neuronal differentiation and prevents apoptosis of terminally differentiated PC12 cells
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1205888
  contributor:
    fullname: el-Ghissassi
– volume: 130
  start-page: 5203
  year: 2003
  ident: 2021042622511838200_DEV178103C77
  article-title: CBF1 controls the retinotectal topographical map along the anteroposterior axis through multiple mechanisms
  publication-title: Development
  doi: 10.1242/dev.00724
  contributor:
    fullname: Takahashi
– volume: 3
  start-page: ENEURO.0169-16.2016
  year: 2016
  ident: 2021042622511838200_DEV178103C87
  article-title: Ipsilateral and contralateral retinal ganglion cells express distinct genes during decussation at the optic chiasm
  publication-title: eNeuro
  doi: 10.1523/ENEURO.0169-16.2016
  contributor:
    fullname: Wang
– volume: 29
  start-page: 3170
  year: 2010
  ident: 2021042622511838200_DEV178103C27
  article-title: Zic2 regulates the expression of Sert to modulate eye-specific refinement at the visual targets
  publication-title: EMBO J.
  doi: 10.1038/emboj.2010.172
  contributor:
    fullname: García-Frigola
– volume: 38
  start-page: 221
  year: 2015
  ident: 2021042622511838200_DEV178103C72
  article-title: The types of retinal ganglion cells: current status and implications for neuronal classification
  publication-title: Annu. Rev. Neurosci.
  doi: 10.1146/annurev-neuro-071714-034120
  contributor:
    fullname: Sanes
– volume: 31
  start-page: 5673
  year: 2011
  ident: 2021042622511838200_DEV178103C8
  article-title: Transcription factor Foxd1 is required for the specification of the temporal retina in mammals
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0394-11.2011
  contributor:
    fullname: Carreres
– volume: 335
  start-page: 418
  year: 2009
  ident: 2021042622511838200_DEV178103C81
  article-title: Robo2 is required for Slit-mediated intraretinal axon guidance
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2009.09.034
  contributor:
    fullname: Thompson
– volume: 85
  start-page: 497
  year: 2015
  ident: 2021042622511838200_DEV178103C51
  article-title: A conserved regulatory logic controls temporal identity in mouse neural progenitors
  publication-title: Neuron
  doi: 10.1016/j.neuron.2014.12.052
  contributor:
    fullname: Mattar
– volume: 328
  start-page: 131
  year: 1987
  ident: 2021042622511838200_DEV178103C83
  article-title: A common progenitor for neurons and glia persists in rat retina late in development
  publication-title: Nature
  doi: 10.1038/328131a0
  contributor:
    fullname: Turner
– volume: 560
  start-page: 494
  year: 2018
  ident: 2021042622511838200_DEV178103C44
  article-title: RNA velocity of single cells
  publication-title: Nature
  doi: 10.1038/s41586-018-0414-6
  contributor:
    fullname: La Manno
– volume: 119
  start-page: 567
  year: 2004
  ident: 2021042622511838200_DEV178103C57
  article-title: Magnitude of binocular vision controlled by islet-2 repression of a genetic program that specifies laterality of retinal axon pathfinding
  publication-title: Cell
  doi: 10.1016/j.cell.2004.10.026
  contributor:
    fullname: Pak
– volume: 109
  start-page: 7882
  year: 2012
  ident: 2021042622511838200_DEV178103C31
  article-title: Transcription factor Olig2 defines subpopulations of retinal progenitor cells biased toward specific cell fates
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1203138109
  contributor:
    fullname: Hafler
– volume: 5
  start-page: e13374
  year: 2016
  ident: 2021042622511838200_DEV178103C96
  article-title: Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation
  publication-title: eLife
  doi: 10.7554/eLife.13374
  contributor:
    fullname: Zheng
– volume: 351
  start-page: 1443
  year: 2016
  ident: 2021042622511838200_DEV178103C79
  article-title: Sequential transcriptional waves direct the differentiation of newborn neurons in the mouse neocortex
  publication-title: Science
  doi: 10.1126/science.aad8361
  contributor:
    fullname: Telley
– volume: 10
  start-page: 57
  year: 2018
  ident: 2021042622511838200_DEV178103C93
  article-title: Single-cell transcriptome analysis of lineage diversity in high-grade glioma
  publication-title: Genome Med.
  doi: 10.1186/s13073-018-0567-9
  contributor:
    fullname: Yuan
– volume: 7
  start-page: 78
  year: 2007
  ident: 2021042622511838200_DEV178103C11
  article-title: Requirement of histone deacetylase activity for the expression of critical photoreceptor genes
  publication-title: BMC Dev. Biol.
  doi: 10.1186/1471-213X-7-78
  contributor:
    fullname: Chen
– volume: 2
  start-page: 109
  year: 2001
  ident: 2021042622511838200_DEV178103C46
  article-title: Vertebrate neural cell-fate determination: lessons from the retina
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/35053522
  contributor:
    fullname: Livesey
– volume: 19
  start-page: 1131
  year: 2016
  ident: 2021042622511838200_DEV178103C63
  article-title: Disentangling neural cell diversity using single-cell transcriptomics
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4366
  contributor:
    fullname: Poulin
– volume: 3
  start-page: e1588
  year: 2008
  ident: 2021042622511838200_DEV178103C82
  article-title: Individual retinal progenitor cells display extensive heterogeneity of gene expression
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0001588
  contributor:
    fullname: Trimarchi
– volume: 36
  start-page: 411
  year: 2018
  ident: 2021042622511838200_DEV178103C6
  article-title: Integrating single-cell transcriptomic data across different conditions, technologies, and species
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4096
  contributor:
    fullname: Butler
– volume: 136
  start-page: 254
  year: 1989
  ident: 2021042622511838200_DEV178103C89
  article-title: Cell lineage analysis reveals multipotent precursors in the ciliary margin of the frog retina
  publication-title: Dev. Biol.
  doi: 10.1016/0012-1606(89)90146-2
  contributor:
    fullname: Wetts
– volume: 296
  start-page: 476
  year: 2006
  ident: 2021042622511838200_DEV178103C80
  article-title: Slits contribute to the guidance of retinal ganglion cell axons in the mammalian optic tract
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2006.06.017
  contributor:
    fullname: Thompson
– volume: 29
  start-page: 1149
  year: 2019
  ident: 2021042622511838200_DEV178103C56
  article-title: A retino-retinal projection guided by Unc5c emerged in species with retinal waves
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2019.02.052
  contributor:
    fullname: Murcia-Belmonte
– volume: 104
  start-page: 12069
  year: 2007
  ident: 2021042622511838200_DEV178103C16
  article-title: A typology of photoreceptor gene expression patterns in the mouse
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0705465104
  contributor:
    fullname: Corbo
– volume: 28
  start-page: 11015
  year: 2008
  ident: 2021042622511838200_DEV178103C7
  article-title: Roles of ephrin-as and structured activity in the development of functional maps in the superior colliculus
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2478-08.2008
  contributor:
    fullname: Cang
– volume: 25
  start-page: 634
  year: 2017
  ident: 2021042622511838200_DEV178103C17
  article-title: Cone genesis tracing by the Chrnb4-EGFP mouse line: evidences of cellular material fusion after cone precursor transplantation
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2016.12.015
  contributor:
    fullname: Decembrini
– volume: 14
  start-page: 979
  year: 2017
  ident: 2021042622511838200_DEV178103C66
  article-title: Reversed graph embedding resolves complex single-cell trajectories
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.4402
  contributor:
    fullname: Qiu
– volume: 20
  start-page: 4975
  year: 2000
  ident: 2021042622511838200_DEV178103C23
  article-title: Retinal ganglion cell axon guidance in the mouse optic chiasm: expression and function of robos and slits
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.20-13-04975.2000
  contributor:
    fullname: Erskine
– volume: 18
  start-page: 2058
  year: 2017
  ident: 2021042622511838200_DEV178103C50
  article-title: Diverse central projection patterns of retinal ganglion cells
  publication-title: Cell Reports
  doi: 10.1016/j.celrep.2017.01.075
  contributor:
    fullname: Martersteck
– volume: 37
  start-page: 1
  year: 2009
  ident: 2021042622511838200_DEV178103C39
  article-title: Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkn923
  contributor:
    fullname: Huang
– volume: 106
  start-page: 9495
  year: 2009
  ident: 2021042622511838200_DEV178103C12
  article-title: Development and diversification of retinal amacrine interneurons at single cell resolution
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0903264106
  contributor:
    fullname: Cherry
– volume: 114
  start-page: 545
  year: 2003
  ident: 2021042622511838200_DEV178103C35
  article-title: Zic2 patterns binocular vision by specifying the uncrossed retinal projection
  publication-title: Cell
  doi: 10.1016/S0092-8674(03)00684-6
  contributor:
    fullname: Herrera
– volume: 35
  start-page: 565
  year: 2012
  ident: 2021042622511838200_DEV178103C1
  article-title: Cell fate determination in the vertebrate retina
  publication-title: Trends Neurosci.
  doi: 10.1016/j.tins.2012.05.004
  contributor:
    fullname: Bassett
– volume: 8
  start-page: 2054
  year: 2018
  ident: 2021042622511838200_DEV178103C99
  article-title: IGFBPL1 regulates axon growth through IGF-1-mediated signaling cascades
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-20463-5
  contributor:
    fullname: Guo
– volume: 75
  start-page: 947
  year: 2015
  ident: 2021042622511838200_DEV178103C40
  article-title: Roles of histone H3K27 trimethylase Ezh2 in retinal proliferation and differentiation
  publication-title: Dev. Neurobiol.
  doi: 10.1002/dneu.22261
  contributor:
    fullname: Iida
– volume: 31
  start-page: 8760
  year: 2011
  ident: 2021042622511838200_DEV178103C70
  article-title: Transgenic mice reveal unexpected diversity of on-off direction-selective retinal ganglion cell subtypes and brain structures involved in motion processing
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0564-11.2011
  contributor:
    fullname: Rivlin-Etzion
– volume: 4
  start-page: 833
  year: 1990
  ident: 2021042622511838200_DEV178103C84
  article-title: Lineage-independent determination of cell type in the embryonic mouse retina
  publication-title: Neuron
  doi: 10.1016/0896-6273(90)90136-4
  contributor:
    fullname: Turner
– volume: 42
  start-page: 84
  year: 2017
  ident: 2021042622511838200_DEV178103C71
  article-title: Timing temporal transitions during brain development
  publication-title: Curr. Opin. Neurobiol.
  doi: 10.1016/j.conb.2016.11.010
  contributor:
    fullname: Rossi
– volume: 39
  start-page: 919
  year: 2003
  ident: 2021042622511838200_DEV178103C91
  article-title: Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm
  publication-title: Neuron
  doi: 10.1016/j.neuron.2003.08.017
  contributor:
    fullname: Williams
– volume: 152
  start-page: 97
  year: 2013
  ident: 2021042622511838200_DEV178103C43
  article-title: Developmentally regulated subnuclear genome reorganization restricts neural progenitor competence in drosophila
  publication-title: Cell
  doi: 10.1016/j.cell.2012.11.049
  contributor:
    fullname: Kohwi
– volume: 29
  start-page: 3463
  year: 2009
  ident: 2021042622511838200_DEV178103C61
  article-title: Specificity and sufficiency of EphB1 in driving the ipsilateral retinal projection
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.5655-08.2009
  contributor:
    fullname: Petros
– volume: 58
  start-page: 5421
  year: 2017
  ident: 2021042622511838200_DEV178103C29
  article-title: The transcription factor Prdm16 marks a single retinal ganglion cell subtype in the mouse retina
  publication-title: Invest. Ophthalmol. Vis. Sci.
  doi: 10.1167/iovs.17-22442
  contributor:
    fullname: Groman-Lupa
– volume: 6
  start-page: e25946
  year: 2017
  ident: 2021042622511838200_DEV178103C13
  article-title: Glycolytic reliance promotes anabolism in photoreceptors
  publication-title: eLife
  doi: 10.7554/eLife.25946
  contributor:
    fullname: Chinchore
– volume: 474
  start-page: 304
  year: 2004
  ident: 2021042622511838200_DEV178103C67
  article-title: Timing and topography of cell genesis in the rat retina
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.20134
  contributor:
    fullname: Rapaport
– volume: 15
  start-page: 4727
  year: 1995
  ident: 2021042622511838200_DEV178103C30
  article-title: Developmental determinants at the mammalian optic chiasm
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.15-07-04727.1995
  contributor:
    fullname: Guillery
– volume: 40
  start-page: 897
  year: 2003
  ident: 2021042622511838200_DEV178103C9
  article-title: Importance of intrinsic mechanisms in cell fate decisions in the developing rat retina
  publication-title: Neuron
  doi: 10.1016/S0896-6273(03)00756-6
  contributor:
    fullname: Cayouette
– volume: 80
  start-page: 9
  year: 2015
  ident: 2021042622511838200_DEV178103C25
  article-title: Visualizing the HoxD gene cluster at the nanoscale level
  publication-title: Cold Spring Harbor Symp. Quant. Biol.
  doi: 10.1101/sqb.2015.80.027177
  contributor:
    fullname: Fabre
– volume: 30
  start-page: 673
  year: 2014
  ident: 2021042622511838200_DEV178103C34
  article-title: Protocadherin-17 mediates collective axon extension by recruiting actin regulator complexes to interaxonal contacts
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2014.07.015
  contributor:
    fullname: Hayashi
– volume: 17
  start-page: 3153
  year: 2016
  ident: 2021042622511838200_DEV178103C48
  article-title: The ciliary margin zone of the mammalian retina generates retinal ganglion cells
  publication-title: Cell Reports
  doi: 10.1016/j.celrep.2016.11.016
  contributor:
    fullname: Marcucci
– volume: 40
  start-page: 137
  year: 2017
  ident: 2021042622511838200_DEV178103C3
  article-title: Msx1-positive progenitors in the retinal ciliary margin give rise to both neural and non-neural progenies in mammals
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2016.11.020
  contributor:
    fullname: Bélanger
– volume: 33
  start-page: 12490
  year: 2013
  ident: 2021042622511838200_DEV178103C92
  article-title: Ten-m2 is required for the generation of binocular visual circuits
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.4708-12.2013
  contributor:
    fullname: Young
– volume: 19
  start-page: 1225
  year: 1997
  ident: 2021042622511838200_DEV178103C54
  article-title: cAMP-dependent growth cone guidance by netrin-1
  publication-title: Neuron
  doi: 10.1016/S0896-6273(00)80414-6
  contributor:
    fullname: Ming
– volume: 350
  start-page: 1251
  year: 2015
  ident: 2021042622511838200_DEV178103C33
  article-title: Single-cell transcriptomics reveals receptor transformations during olfactory neurogenesis
  publication-title: Science
  doi: 10.1126/science.aad2456
  contributor:
    fullname: Hanchate
– volume: 100
  start-page: 5491
  year: 2003
  ident: 2021042622511838200_DEV178103C19
  article-title: Analysis of gene expression in the developing mouse retina
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0831080100
  contributor:
    fullname: Díaz
– volume: 31
  start-page: 295
  year: 2008
  ident: 2021042622511838200_DEV178103C60
  article-title: Retinal axon growth at the optic chiasm: to cross or not to cross
  publication-title: Annu. Rev. Neurosci.
  doi: 10.1146/annurev.neuro.31.060407.125609
  contributor:
    fullname: Petros
– volume: 239
  start-page: 1142
  year: 1988
  ident: 2021042622511838200_DEV178103C88
  article-title: Multipotent precursors can give rise to all major cell types of the frog retina
  publication-title: Science
  doi: 10.1126/science.2449732
  contributor:
    fullname: Wetts
– volume: 5
  start-page: 955
  year: 2002
  ident: 2021042622511838200_DEV178103C75
  article-title: Age-related changes underlie switch in netrin-1 responsiveness as growth cones advance along visual pathway
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn919
  contributor:
    fullname: Shewan
– volume: 5
  start-page: e241
  year: 2007
  ident: 2021042622511838200_DEV178103C45
  article-title: Ten_m3 regulates eye-specific patterning in the mammalian visual pathway and is required for binocular vision
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.0050241
  contributor:
    fullname: Leamey
– volume: 126
  start-page: 555
  year: 1999
  ident: 2021042622511838200_DEV178103C4
  article-title: Extrinsic and intrinsic factors control the genesis of amacrine and cone cells in the rat retina
  publication-title: Development
  doi: 10.1242/dev.126.3.555
  contributor:
    fullname: Belliveau
– volume: 131
  start-page: 5727
  year: 2004
  ident: 2021042622511838200_DEV178103C36
  article-title: Foxd1 is required for proper formation of the optic chiasm
  publication-title: Development
  doi: 10.1242/dev.01431
  contributor:
    fullname: Herrera
– volume: 97
  start-page: 326
  year: 2018
  ident: 2021042622511838200_DEV178103C58
  article-title: Sonic hedgehog is a remotely produced cue that controls axon guidance trans-axonally at a midline choice point
  publication-title: Neuron
  doi: 10.1016/j.neuron.2017.12.028
  contributor:
    fullname: Peng
– volume: 30
  start-page: 266
  year: 2010
  ident: 2021042622511838200_DEV178103C24
  article-title: Segregation of ipsilateral retinal ganglion cell axons at the optic chiasm requires the Shh receptor Boc
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3778-09.2010
  contributor:
    fullname: Fabre
– volume: 86
  year: 2013
  ident: 2021042622511838200_DEV178103C86
  article-title: A smart local moving algorithm for large-scale modularity-based community detection
  publication-title: Eur. Phys. J. B
  doi: 10.1140/epjb/e2013-40829-0
  contributor:
    fullname: Waltman
– volume: 348
  start-page: 340
  year: 2015
  ident: 2021042622511838200_DEV178103C41
  article-title: Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness
  publication-title: Science
  doi: 10.1126/science.1260384
  contributor:
    fullname: Katajisto
– volume: 26
  start-page: 59
  year: 2013
  ident: 2021042622511838200_DEV178103C22
  article-title: Otx2 and onecut1 promote the fates of cone photoreceptors and horizontal cells and repress rod photoreceptors
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2013.06.005
  contributor:
    fullname: Emerson
– volume: 63
  start-page: 167
  year: 1990
  ident: 2021042622511838200_DEV178103C90
  article-title: Identification of a ligand for the c-kit proto-oncogene
  publication-title: Cell
  doi: 10.1016/0092-8674(90)90297-R
  contributor:
    fullname: Williams
– volume: 119
  start-page: 49
  year: 1993
  ident: 2021042622511838200_DEV178103C37
  article-title: Stem cell factor induces outgrowth of c-kit-positive neurites and supports the survival of c-kit-positive neurons in dorsal root ganglia of mouse embryos
  publication-title: Development
  doi: 10.1242/dev.119.1.49
  contributor:
    fullname: Hirata
– volume: 108
  start-page: 515
  year: 1990
  ident: 2021042622511838200_DEV178103C15
  article-title: The early development of retinal ganglion cells with uncrossed axons in the mouse: retinal position and axonal course
  publication-title: Development
  doi: 10.1242/dev.108.3.515
  contributor:
    fullname: Colello
– volume: 102
  start-page: 1111
  year: 2019
  ident: 2021042622511838200_DEV178103C14
  article-title: Single-cell RNA-seq analysis of retinal development identifies NFI factors as regulating mitotic exit and late-born cell specification
  publication-title: Neuron
  doi: 10.1016/j.neuron.2019.04.010
  contributor:
    fullname: Clark
– volume: 2008
  start-page: P10008
  year: 2008
  ident: 2021042622511838200_DEV178103C98
  article-title: Fast unfolding of communities in large networks
  publication-title: J. Stat. Mech.
  doi: 10.1088/1742-5468/2008/10/P10008
  contributor:
    fullname: Blondel
– volume: 15
  start-page: 615
  year: 2014
  ident: 2021042622511838200_DEV178103C10
  article-title: Intrinsically different retinal progenitor cells produce specific types of progeny
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn3767
  contributor:
    fullname: Cepko
– volume: 4
  start-page: 44
  year: 2008
  ident: 2021042622511838200_DEV178103C38
  article-title: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2008.211
  contributor:
    fullname: Huang
– volume: 3
  start-page: 861
  year: 2018
  ident: 2021042622511838200_DEV178103C52
  article-title: UMAP: uniform manifold approximation and projection
  publication-title: JOSS
  doi: 10.21105/joss.00861
  contributor:
    fullname: McInnes
– volume: 40
  start-page: 616
  year: 2003
  ident: 2021042622511838200_DEV178103C32
  article-title: Evidence of RPGRIP1 gene mutations associated with recessive cone-rod dystrophy
  publication-title: J. Med. Genet.
  doi: 10.1136/jmg.40.8.616
  contributor:
    fullname: Hameed
– volume: 174
  start-page: 999
  year: 2018
  ident: 2021042622511838200_DEV178103C95
  article-title: Molecular architecture of the mouse nervous system
  publication-title: Cell
  doi: 10.1016/j.cell.2018.06.021
  contributor:
    fullname: Zeisel
– volume: 16
  start-page: 101
  year: 2018
  ident: 2021042622511838200_DEV178103C26
  article-title: Heterogeneous combinatorial expression of Hoxd genes in single cells during limb development
  publication-title: BMC Biol.
  doi: 10.1186/s12915-018-0570-z
  contributor:
    fullname: Fabre
– volume: 19
  start-page: 335
  year: 2016
  ident: 2021042622511838200_DEV178103C78
  article-title: Adult mouse cortical cell taxonomy revealed by single cell transcriptomics
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4216
  contributor:
    fullname: Tasic
– volume: 166
  start-page: 1308
  year: 2016
  ident: 2021042622511838200_DEV178103C74
  article-title: Comprehensive classification of retinal bipolar neurons by single-cell transcriptomics
  publication-title: Cell
  doi: 10.1016/j.cell.2016.07.054
  contributor:
    fullname: Shekhar
– volume: 161
  start-page: 1202
  year: 2015
  ident: 2021042622511838200_DEV178103C47
  article-title: Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets
  publication-title: Cell
  doi: 10.1016/j.cell.2015.05.002
  contributor:
    fullname: Macosko
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Snippet Retinal ganglion cells (RGCs), cone photoreceptors (cones), horizontal cells and amacrine cells are the first classes of neurons produced in the retina....
Retinal ganglion cells (RGC), cone photoreceptors (cones), horizontal cells (HC) and amacrine cells (AC) are the first classes of neurons produced in the...
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Title Single-cell transcriptional logic of cell-fate specification and axon guidance in early-born retinal neurons
URI https://www.ncbi.nlm.nih.gov/pubmed/31399471
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