Exploitation of porphyrin-based titanium-rich porous organic polymers for targeted phosphopeptide enrichment from the serum of colorectal cancer individuals

• Published in: Mikrochimica acta (1966) Vol. 191; no. 8; p. 487
• Main Authors: Wang, Danni, Sheng, Xiuqin, Shao, Jiahui, Ding, Chuan-Fan, Yan, Yinghua
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.08.2024; Springer; Springer Nature B.V
• Subjects: Analytical Chemistry; Cancer; Casein; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Colorectal cancer; Colorectal Neoplasms - blood; Estrogen; Estrogens; Heparin; Humans; Inflammatory response; Microengineering; Nanochemistry; Nanotechnology; Original Paper; Pathogenesis; Phosphopeptides - blood; Phosphopeptides - chemistry; Phosphopeptides - isolation & purification; Phosphoproteins; Polymer industry; Polymers; Polymers - chemistry; Porosity; Porphyrins; Porphyrins - chemistry; Raw materials; Titanium; Titanium - chemistry; Phosphopeptides; Nano-LC–MS/MS; Analyte enrichment; Colorectal cancer

A porphyrin-based titanium-rich porous organic polymer (Th-PPOPs@Ti 4+ ) was designed based on immobilized metal ion affinity chromatography technique and successfully applied to phosphopeptide enrichment with 5,10,15,20-tetrakis(4-carboxyphenyl) porphine tetramethyl ester (TCPTE), 2,3-dihydroxytere...