Non-spherical oscillations drive the ultrasound-mediated release from targeted microbubbles

• Published in: Communications physics Vol. 1; no. 1
• Main Authors: Lajoinie, Guillaume, Luan, Ying, Gelderblom, Erik, Dollet, Benjamin, Mastik, Frits, Dewitte, Heleen, Lentacker, Ine, de Jong, Nico, Versluis, Michel
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 31.05.2018; Nature Publishing Group; Nature Research
• Subjects: 639/766/189; 639/766/25/3927; Bioengineering; Drug delivery systems; Fluid mechanics; Fluorescence; High speed; Imaging; Life Sciences; Mechanics; Oscillations; Physics; Physics and Astronomy; Transport vehicles; Ultrasonic imaging; Ultrasound

Ultrasound-driven microbubbles are attractive for a variety of applications in medicine, including real-time organ perfusion imaging and targeted molecular imaging. In ultrasound-mediated drug delivery, bubbles decorated with a functional payload become convenient transport vehicles and offer highly...