Nel positively regulates the genesis of retinal ganglion cells by promoting their differentiation and survival during development

• Published in: Molecular biology of the cell Vol. 25; no. 2; pp. 234 - 244
• Main Authors: Nakamoto, Chizu, Kuan, Soh-Leh, Findlay, Amy S, Durward, Elaine, Ouyang, Zhufeng, Zakrzewska, Ewa D, Endo, Takuma, Nakamoto, Masaru
• Format: Journal Article
• Language: English
• Published: United States The American Society for Cell Biology 15.01.2014
• Subjects: Animals; Apoptosis - genetics; Avian Proteins - genetics; Cell Differentiation - genetics; Cell Survival - genetics; Chickens; Gene Expression Regulation, Developmental; Glycoproteins - genetics; Retina - growth & development; Retina - metabolism; Retinal Ganglion Cells; Stem Cells - cytology; Stem Cells - metabolism; Thrombospondins - genetics; Thrombospondins - metabolism

For correct functioning of the nervous system, the appropriate number and complement of neuronal cell types must be produced during development. However, the molecular mechanisms that regulate the production of individual classes of neurons are poorly understood. In this study, we investigate the fu...