Human Kallikrein 4: Quantitative Study in Tissues and Evidence for Its Secretion into Biological Fluids

• Published in: Clinical chemistry (Baltimore, Md.) Vol. 51; no. 8; pp. 1432 - 1442
• Main Authors: Obiezu, Christina V, Shan, Shannon J.C, Soosaipillai, Antoninus, Luo, Liu-Ying, Grass, Linda, Sotiropoulou, Georgia, Petraki, Constantina D, Papanastasiou, Panos A, Levesque, Michael A, Diamandis, Eleftherios P
• Format: Journal Article
• Language: English
• Published: Washington, DC Am Assoc Clin Chem 01.08.2005; American Association for Clinical Chemistry; Oxford University Press
• Subjects: Analytical, structural and metabolic biochemistry; Androgens; Animals; Antibodies; Antibodies, Monoclonal; Biological and medical sciences; Body Fluids - chemistry; Cloning; Endometrial cancer; Enzyme-Linked Immunosorbent Assay; Enzymes; Female; Fluorescent Antibody Technique; Fundamental and applied biological sciences. Psychology; Humans; Immunoassay; Immunoenzyme Techniques; Investigative techniques, diagnostic techniques (general aspects); Kallikreins - analysis; Kallikreins - blood; Kallikreins - metabolism; Kallikreins - urine; Male; Mass spectrometry; Medical sciences; Mice; Mice, Inbred BALB C; Organ Specificity; Ovarian cancer; Plasma; Prostate - chemistry; Prostate cancer; Prostatic Neoplasms - chemistry; Proteins; Quantitative research; Rabbits; Recombinant Proteins - biosynthesis; Recombinant Proteins - immunology; Recombinant Proteins - isolation & purification; Semen - chemistry; Tissues; Urine; Human; Biological fluid; Vasodilator agent; Serine endopeptidases; Enzyme; Secretion; Biochemistry; Peptidases; Clinical biology; Plasma kallikrein; Hydrolases; Molecular biology; Quantitative analysis

Human kallikrein 4 (hK4) is a proteolytic enzyme belonging to the tissue kallikrein family of serine proteases. Previous tissue expression studies have demonstrated highest KLK4 mRNA expression in prostatic tissue, but there has been only limited evidence for the presence of hK4 protein in prostate...