“Wait anaphase” signals are not confined to the mitotic spindle

• Published in: Molecular biology of the cell Vol. 28; no. 9; pp. 1186 - 1194
• Main Authors: Heasley, Lydia R., Markus, Steven M., DeLuca, Jennifer G.
• Format: Journal Article
• Language: English
• Published: United States The American Society for Cell Biology 01.05.2017
• Subjects: Anaphase - physiology; Anaphase-Promoting Complex-Cyclosome - genetics; Cell Culture Techniques; Cell Cycle Checkpoints; Cell Cycle Proteins - genetics; Humans; Kinetochores - physiology; M Phase Cell Cycle Checkpoints - genetics; M Phase Cell Cycle Checkpoints - physiology; Microtubules; Mitosis; Protein-Serine-Threonine Kinases - genetics; Spindle Apparatus - genetics; Spindle Apparatus - physiology

The spindle assembly checkpoint ensures the faithful inheritance of chromosomes by arresting mitotic progression in the presence of kinetochores that are not attached to spindle microtubules. This is achieved through inhibition of the anaphase-promoting complex/cyclosome by a kinetochore-derived “wa...