Perfluoroheptanoic acid affects amphibian embryogenesis by inducing the phosphorylation of ERK and JNK

• Published in: International journal of molecular medicine Vol. 36; no. 6; pp. 1693 - 1700
• Main Authors: KIM, MIRAN, PARK, MI SEON, SON, JUNGEUN, PARK, INJI, LEE, HYUN-KYUNG, KIM, CHOWON, MIN, BYUNG-HWA, RYOO, JAEWOONG, CHOI, KWANG SHIK, LEE, DONG-SEOK, LEE, HYUN-SHIK
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.12.2015; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Acids; Animals; Blotting, Western; Caproates - toxicity; Carbon; Carcinogenesis; Cellular signal transduction; developmental toxicity; Embryo, Nonmammalian - drug effects; Embryo, Nonmammalian - embryology; Embryo, Nonmammalian - metabolism; embryogenesis; Extracellular Signal-Regulated MAP Kinases - metabolism; Fluorine; Fluorocarbons - toxicity; Gene expression; Gene Expression Regulation, Developmental - drug effects; Genetic aspects; Health aspects; Heart; Heart - drug effects; Heart - embryology; Heptanoic Acids - toxicity; In Situ Hybridization; JNK Mitogen-Activated Protein Kinases - metabolism; Kinases; Laboratory animals; Larva - drug effects; Larva - genetics; Larva - metabolism; Liver; Liver - drug effects; Liver - embryology; Liver - pathology; Myocardium - metabolism; Myocardium - pathology; perfluoroalkyl compounds; Perfluorocarbons; Phosphorylation; Phosphorylation - drug effects; Polymerase chain reaction; Reverse Transcriptase Polymerase Chain Reaction; Risk factors; Studies; teratogenicity; Toxicity; Xenopus; Xenopus laevis - embryology; Xenopus laevis - genetics; Xenopus laevis - metabolism; Xenopus Proteins - genetics; Xenopus Proteins - metabolism

Perfluoroalkyl compounds (PFCs) are globally distributed synthetic compounds that are known to adversely affect human health. Developmental toxicity assessment of PFCs is important to facilitate the evaluation of their environmental impact. In the present study, we assessed the developmental toxicit...