Suppression of α-catenin and adherens junctions enhances epithelial cell proliferation and motility via TACE-mediated TGF-α autocrine/paracrine signaling

• Published in: Molecular biology of the cell Vol. 32; no. 4; pp. 348 - 361
• Main Authors: Bunker, Eric N, Wheeler, Graycen E, Chapnick, Douglas A, Liu, Xuedong
• Format: Journal Article
• Language: English
• Published: United States The American Society for Cell Biology 15.02.2021
• Subjects: ADAM17 Protein - metabolism; ADAM17 Protein - physiology; Adherens Junctions - metabolism; Adherens Junctions - physiology; alpha Catenin - metabolism; alpha Catenin - physiology; Cell Line, Tumor; Cell Movement - physiology; Cell Proliferation; Epidermal Growth Factor - metabolism; Epithelial Cells - metabolism; ErbB Receptors - metabolism; HaCaT Cells; Humans; Metalloproteases - metabolism; Paracrine Communication - physiology; Phosphorylation; Signal Transduction; Transforming Growth Factor alpha - metabolism

Sustained cell migration is essential for wound healing and cancer metastasis. The epidermal growth factor receptor (EGFR) signaling cascade is known to drive cell migration and proliferation. While the signal transduction downstream of EGFR has been extensively investigated, our knowledge of the in...