Meningococcal ACWY conjugate vaccine immunogenicity and safety in adolescents with juvenile idiopathic arthritis and inflammatory bowel disease: A prospective observational cohort study

• Published in: Vaccine Vol. 41; no. 25; pp. 3782 - 3789
• Main Authors: Ohm, Milou, van Straalen, Joeri W., Zijlstra, Marieke, de Joode-Smink, Gerrie, Sellies, Anne Jasmijn, Swart, Joost F., Vastert, Sebastiaan J., van Montfrans, Joris M., Bartels, Marije, van Royen-Kerkhof, Annet, Wildenbeest, Joanne G., Lindemans, Caroline A., Wolters, Victorien M., Wennink, Roos A.W., de Boer, Joke H., Knol, Mirjam J., Heijstek, Marloes W., Sanders, Elisabeth A.M., Verduyn-Lunel, Frans M., Berbers, Guy A.M., Wulffraat, Nico M., Jansen, Marc H.A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 07.06.2023; Elsevier Limited
• Subjects: Adolescent; Adolescents; Age; Anti-TNF agents; Antibodies; Antibodies, Bacterial; Arthritis; Arthritis, Juvenile - drug therapy; Biologicals; Cohort analysis; Conjugates; Drug dosages; Drug therapy; Health care; Humans; Immune system; Immunocompromised; Immunogenicity; Immunogenicity, Vaccine; Immunoglobulin G; Inflammatory bowel disease; Inflammatory bowel diseases; Intestine; Juvenile idiopathic arthritis; Medical research; MenACWY vaccination; Meningococcal Infections - prevention & control; Meningococcal Vaccines - adverse effects; Observational studies; Patients; Pediatrics; Polysaccharides; Prospective Studies; Public health; Safety; Serology; Teenagers; TNF inhibitors; Tumor necrosis factor; Tumor necrosis factor-TNF; Vaccines; Vaccines, Conjugate - adverse effects; Netherlands; Inflammatory bowel disease; Anti-TNF agents; MenACWY vaccination; Immunogenicity; Immunocompromised; Safety; Adolescents; Juvenile idiopathic arthritis; Biologicals

Immunogenicity to meningococcal serogroup ACWY (MenACWY) conjugate vaccine has not been studied in immunocompromised minors with juvenile idiopathic arthritis (JIA) or inflammatory bowel disease (IBD). We determined immunogenicity of a MenACWY-TT vaccine in JIA and IBD patients at adolescent age and...