Meningococcal ACWY conjugate vaccine immunogenicity and safety in adolescents with juvenile idiopathic arthritis and inflammatory bowel disease: A prospective observational cohort study

• Published in: Vaccine Vol. 41; no. 25; pp. 3782 - 3789
• Main Authors: Ohm, Milou, van Straalen, Joeri W., Zijlstra, Marieke, de Joode-Smink, Gerrie, Sellies, Anne Jasmijn, Swart, Joost F., Vastert, Sebastiaan J., van Montfrans, Joris M., Bartels, Marije, van Royen-Kerkhof, Annet, Wildenbeest, Joanne G., Lindemans, Caroline A., Wolters, Victorien M., Wennink, Roos A.W., de Boer, Joke H., Knol, Mirjam J., Heijstek, Marloes W., Sanders, Elisabeth A.M., Verduyn-Lunel, Frans M., Berbers, Guy A.M., Wulffraat, Nico M., Jansen, Marc H.A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 07.06.2023; Elsevier Limited
• Subjects: Adolescent; Adolescents; Age; Anti-TNF agents; Antibodies; Antibodies, Bacterial; Arthritis; Arthritis, Juvenile - drug therapy; Biologicals; Cohort analysis; Conjugates; Drug dosages; Drug therapy; Health care; Humans; Immune system; Immunocompromised; Immunogenicity; Immunogenicity, Vaccine; Immunoglobulin G; Inflammatory bowel disease; Inflammatory bowel diseases; Intestine; Juvenile idiopathic arthritis; Medical research; MenACWY vaccination; Meningococcal Infections - prevention & control; Meningococcal Vaccines - adverse effects; Observational studies; Patients; Pediatrics; Polysaccharides; Prospective Studies; Public health; Safety; Serology; Teenagers; TNF inhibitors; Tumor necrosis factor; Tumor necrosis factor-TNF; Vaccines; Vaccines, Conjugate - adverse effects; Netherlands; Inflammatory bowel disease; Anti-TNF agents; MenACWY vaccination; Immunogenicity; Immunocompromised; Safety; Adolescents; Juvenile idiopathic arthritis; Biologicals
• DOI: 10.1016/j.vaccine.2023.04.056
• ISSN: 0264-410X; 1873-2518

Immunogenicity to meningococcal serogroup ACWY (MenACWY) conjugate vaccine has not been studied in immunocompromised minors with juvenile idiopathic arthritis (JIA) or inflammatory bowel disease (IBD). We determined immunogenicity of a MenACWY-TT vaccine in JIA and IBD patients at adolescent age and compared results to data from aged-matched healthy controls (HCs). We performed a prospective observational cohort study in JIA and IBD patients (14–18 years old), who received a MenACWY vaccination during a nationwide catch-up campaign (2018–2019) in the Netherlands. Primary aim was to compare MenACWY polysaccharide-specific serum IgG geometric mean concentrations (GMCs) in patients with HCs and secondary between patients with or without anti-TNF therapy. GMCs were determined before and 3–6, 12, and 24 months postvaccination and compared with data from HCs at baseline and 12 months postvaccination. Serum bactericidal antibody (SBA) titers were determined in a subset of patients at 12 months postvaccination. We included 226 JIA and IBD patients (66 % and 34 % respectively). GMCs were lower for MenA and MenW (GMC ratio 0·24 [0·17-0·34] and 0·16 [0·10-0·26] respectively, p < 0·01) in patients compared to HCs at 12 months postvaccination. Anti-TNF users had lower MenACWY GMCs postvaccination compared with those without anti-TNF (p < 0·01). The proportion protected (SBA ≥ 8) for MenW was reduced in anti-TNF users (76 % versus 92 % in non-anti-TNF and 100 % in HCs, p < 0.01). The MenACWY conjugate vaccine was immunogenic in the vast majority of JIA and IBD patients at adolescent age, but seroprotection was lower in patients using anti-TNF agents. Therefore, an extra booster MenACWY vaccination should be considered.