Catalyst-free synthesis of quinazoline derivatives using low melting sugar–urea–salt mixture as a solvent

• Published in: Green chemistry : an international journal and green chemistry resource : GC Vol. 14; no. 5; pp. 1502 - 1506
• Main Authors: Zhang, Zhan-Hui, Zhang, Xiao-Nan, Mo, Li-Ping, Li, Yong-Xiao, Ma, Fei-Ping
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 01.05.2012; Royal Society of Chemistry
• Subjects: aldehydes; ammonium acetate; biodegradability; Carbohydrates with 4, 5, 6, ... C atoms, dissacharides and oligosaccharides; Carbohydrates. Nucleosides and nucleotides; Chemistry; Chemistry, Multidisciplinary; Exact sciences and technology; Green & Sustainable Science & Technology; green chemistry; Heterocyclic compounds; Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings; ketones; melting; Organic chemistry; oxidation; Physical Sciences; Preparations and properties; Science & Technology; Science & Technology - Other Topics; solvents; MULTICOMPONENT REACTIONS; REACTION MEDIA; HETEROCYCLES; ORGANIC-REACTIONS; ANTIINFLAMMATORY EVALUATION; MAGNETICALLY SEPARABLE CATALYST; ONE-POT PROCEDURE; POLYETHYLENE-GLYCOL; EFFICIENT; WATER; One pot reaction; Melting; Multicomponent reaction; Nitrogen heterocycle; Quinazoline derivatives; Oside; Aerobe; Maltose; Aldehyde; Ketone; Ammonium chloride; Urea; Catalyst-free reaction; Ureas; Oxidation; Chemical synthesis; Solvent; Ammonium Chlorides
• ISSN: 1463-9262; 1463-9270; 1463-9270
• DOI: 10.1039/c2gc35258c

Low melting mixture of maltose-dimethylurea (DMU)-NH4Cl was found to be an inexpensive, non-toxic, easily biodegradable and effective reaction medium in the catalyst-free synthesis of quinazoline derivatives. This simple and efficient method furnished the corresponding quinazolines in high yields via one-pot three-component reaction of 2-aminoaryl ketones, aldehyde, and ammonium acetate under aerobic oxidation conditions.