Relationship between oxidized fibrinogen and hemostasis disturbances and endothelial dysfunction in myocardial infarction

Oxidative modification of fibrinogen in acute myocardial infarction increased 1.3-fold compared to that in CHD and 1.5-fold surpassed that in the control without CHD. Elevated content of oxidized fibrinogen correlated with increased levels of LPO products, von Willebrand factor, and fibrin degradati...

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Published inBulletin of experimental biology and medicine Vol. 145; no. 4; pp. 412 - 414
Main Authors Ragino, Yu. I, Baum, V. A, Polonskaya, Ya. V, Sadovski, E. V, Baum, S. R, Nikitin, Yu. P
Format Journal Article
LanguageEnglish
Published Boston Boston : Springer US 01.04.2008
Springer US
Springer Nature B.V
Subjects
Adult
Aged
Biomedical and Life Sciences
Biomedicine
Blood Coagulation Disorders - blood
Blood Coagulation Disorders - metabolism
Blood Coagulation Disorders - physiopathology
Case-Control Studies
Cell Biology
endothelial dysfunction
Endothelium, Vascular - metabolism
Endothelium, Vascular - physiopathology
Fibrinogen - metabolism
Hemostasis - physiology
hemostasis disturbances
Humans
Internal Medicine
Laboratory Medicine
Lipid Peroxidation - physiology
Male
Middle Aged
myocardial infarction
Myocardial Infarction - blood
Myocardial Infarction - metabolism
Myocardial Infarction - physiopathology
Oxidation-Reduction
oxidized fibrinogen
oxidized lipids and proteins
Pathology
Vascular Diseases - blood
Vascular Diseases - metabolism
Vascular Diseases - physiopathology
oxidized lipids and proteins
hemostasis disturbances
endothelial dysfunction
oxidized fibrinogen
myocardial infarction
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Summary:Oxidative modification of fibrinogen in acute myocardial infarction increased 1.3-fold compared to that in CHD and 1.5-fold surpassed that in the control without CHD. Elevated content of oxidized fibrinogen correlated with increased levels of LPO products, von Willebrand factor, and fibrin degradation products, with accelerated leukocyte and platelet aggregation, and reduced content of NO metabolites in the plasma. Independent associations of oxidized fibrinogen with myocardial infarction and typical thrombogenic and hypercoagulation hemostasis disorders and endothelial dysfunctions were revealed.
Bibliography:http://dx.doi.org/10.1007/s10517-008-0104-8
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-008-0104-8