Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review

Amyloidosis is a rare disease that is often seen in conjunction with multiple myeloma (MM). Its damage varies depending on the anatomical site affected; however, it is believed that many cases of amyloidosis are misrecognized due to the fact that its signs and symptoms are nonspecific. Joint amyloid...

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Published inHematology reports Vol. 14; no. 1; pp. 19 - 23
Main Authors Mazziotta, Francesco, Buda, Gabriele, Del Giudice, Maria Livia, Orciuolo, Enrico, Benedetti, Edoardo, Masini, Matilde, De Tata, Vincenzo, Galimberti, Sara, Petrini, Mario
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 02.03.2022
MDPI
Subjects
Amyloidosis
Arthritis
Autoimmune diseases
Biopsy
Bone marrow
Case Report
Conflicts of interest
Diagnosis
Hematology
immunoglobulin light-chain amyloidosis
joint diseases
Light
Literature reviews
Medical imaging
Microscopy
Multiple myeloma
Patients
plasma cell neoplasm
Stem cells
Transplants & implants
Ultrasonic imaging
multiple myeloma
immunoglobulin light-chain amyloidosis
joint diseases
plasma cell neoplasm
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Abstract Amyloidosis is a rare disease that is often seen in conjunction with multiple myeloma (MM). Its damage varies depending on the anatomical site affected; however, it is believed that many cases of amyloidosis are misrecognized due to the fact that its signs and symptoms are nonspecific. Joint amyloidosis, in particular, may be confused with degenerative or autoimmune diseases. When it is associated with MM, it can significantly precede the diagnosis of the latter. We describe a case report of a woman of Nigerian heritage diagnosed with MM with widespread joint manifestations compatible with a diagnosis of amyloidosis, which had preceded the diagnosis of MM and benefited from MM treatment. Faced with the suspicion of amyloidosis, if confirmed, this can be used to anticipate the diagnosis of MM, and at a more advanced stage, it can benefit from the treatment of the MM.
AbstractList Amyloidosis is a rare disease that is often seen in conjunction with multiple myeloma (MM). Its damage varies depending on the anatomical site affected; however, it is believed that many cases of amyloidosis are misrecognized due to the fact that its signs and symptoms are nonspecific. Joint amyloidosis, in particular, may be confused with degenerative or autoimmune diseases. When it is associated with MM, it can significantly precede the diagnosis of the latter. We describe a case report of a woman of Nigerian heritage diagnosed with MM with widespread joint manifestations compatible with a diagnosis of amyloidosis, which had preceded the diagnosis of MM and benefited from MM treatment. Faced with the suspicion of amyloidosis, if confirmed, this can be used to anticipate the diagnosis of MM, and at a more advanced stage, it can benefit from the treatment of the MM.
Author De Tata, Vincenzo
Galimberti, Sara
Mazziotta, Francesco
Benedetti, Edoardo
Orciuolo, Enrico
Masini, Matilde
Del Giudice, Maria Livia
Petrini, Mario
Buda, Gabriele
AuthorAffiliation 2 Department of Translational Research and New Technologies in Medicine and Surgery, Pisa University Hospital, 56126 Pisa, Italy; matilde.masini@unipi.it (M.M.); vincenzo.detata@unipi.it (V.D.T.)
1 Hematology Division, Pisa University Hospital, 56126 Pisa, Italy; francemazziotta@gmail.com (F.M.); ga.buda@libero.it (G.B.); e.orciuolo@alumni.sssup.it (E.O.); edobenedetti@gmail.com (E.B.); sara.galimberti@unipi.it (S.G.); mario.petrini@unipi.it (M.P.)
AuthorAffiliation_xml – name: 1 Hematology Division, Pisa University Hospital, 56126 Pisa, Italy; francemazziotta@gmail.com (F.M.); ga.buda@libero.it (G.B.); e.orciuolo@alumni.sssup.it (E.O.); edobenedetti@gmail.com (E.B.); sara.galimberti@unipi.it (S.G.); mario.petrini@unipi.it (M.P.)
– name: 2 Department of Translational Research and New Technologies in Medicine and Surgery, Pisa University Hospital, 56126 Pisa, Italy; matilde.masini@unipi.it (M.M.); vincenzo.detata@unipi.it (V.D.T.)
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10.1182/blood-2014-11-609883
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ContentType Journal Article
Copyright 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2022 by the authors. 2022
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Issue 1
Keywords multiple myeloma
immunoglobulin light-chain amyloidosis
joint diseases
plasma cell neoplasm
Language English
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Snippet Amyloidosis is a rare disease that is often seen in conjunction with multiple myeloma (MM). Its damage varies depending on the anatomical site affected;...
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SubjectTerms Amyloidosis
Arthritis
Autoimmune diseases
Biopsy
Bone marrow
Case Report
Conflicts of interest
Diagnosis
Hematology
immunoglobulin light-chain amyloidosis
joint diseases
Light
Literature reviews
Medical imaging
Microscopy
Multiple myeloma
Patients
plasma cell neoplasm
Stem cells
Transplants & implants
Ultrasonic imaging
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Title Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review
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