Effects of endoplasmic reticulum stress on the expression of inflammatory cytokines in patients with ulcerative colitis

• Published in: World journal of gastroenterology : WJG Vol. 22; no. 7; pp. 2357 - 2365
• Main Authors: Li, Nan, Wang, Xue-Ming, Jiang, Li-Jun, Zhang, Meng, Li, Na, Wei, Zhen-Zhen, Zheng, Nan, Zhao, Ya-Jiao
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 21.02.2016
• Subjects: Adult; Case-Control Studies; Cells, Cultured; Clinical Trials Study; Colitis, Ulcerative - blood; Colitis, Ulcerative - genetics; Colitis, Ulcerative - immunology; Colitis, Ulcerative - metabolism; Cytokines - genetics; Cytokines - immunology; Cytokines - metabolism; Endoplasmic Reticulum Stress - drug effects; Female; Humans; Inflammation Mediators - immunology; Inflammation Mediators - metabolism; Interferon-gamma - genetics; Interferon-gamma - metabolism; Interleukin-17 - genetics; Interleukin-17 - metabolism; Interleukin-2 - genetics; Interleukin-2 - metabolism; Lymphocyte Activation; Male; Middle Aged; Phytohemagglutinins - pharmacology; Signal Transduction; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Thapsigargin - pharmacology; Up-Regulation; X-Box Binding Protein 1 - genetics; X-Box Binding Protein 1 - metabolism; Young Adult; X-box binding protein 1 splicing; Endoplasmic reticulum stress; Ulcerative colitis

To explore the changes of X-box binding protein 1 splicing (XBP1s) and inflammatory cytokine expression in patients with ulcerative colitis (UC) in response to endoplasmic reticulum stress (ERS). Reverse transcription polymerase chain reaction and quantitative polymerase chain reaction were performe...