Tight junction protein ZO-2 modulates the nuclear accumulation of transcription factor TEAD

• Published in: Molecular biology of the cell Vol. 32; no. 15; pp. 1347 - 1358
• Main Authors: Gallego-Gutiérrez, Helios, González-González, Laura, Ramírez-Martínez, Leticia, López-Bayghen, Esther, González-Mariscal, Lorenza
• Format: Journal Article
• Language: English
• Published: United States The American Society for Cell Biology 15.07.2021
• Subjects: Animals; Cell Line; Cell Nucleus - metabolism; Dogs; Epithelial Cells - metabolism; HEK293 Cells; Humans; Nuclear Localization Signals; Phosphorylation; Protein Binding; Protein Kinase C-epsilon - metabolism; Protein Processing, Post-Translational; Protein Transport; Rats; Signal Transduction; TEA Domain Transcription Factors - metabolism; Zonula Occludens-2 Protein - metabolism

The presence of tight junction protein onula ccludens 2 (ZO-2) at the nucleus inhibits the transcription of genes regulated by TEAD transcription factor. Here, we analyzed whether the movement of ZO-2 into the nucleus modulates the nuclear concentration of TEAD. In sparse cultures of ZO-2 knockdown...