Development of a rapidly dispersing tablet of a poorly wettable compound—formulation DOE and mechanistic study of effect of formulation excipients on wetting of celecoxib - He, Xiaorong; Barone, Michael R.; Marsac, Patrick J.; Sperry, David C. (International journal of pharmaceutics, 2008)
Keywords: Agglomeration; Biological and medical sciences; Celecoxib; Chemistry, Pharmaceutical; Disintegration; Dispersion; Excipients; General pharmacology; Medical sciences; Nephelometry and Turbidimetry; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Poorly soluble; Porosity; Pyrazoles - administration & dosage; Pyrazoles - chemistry; Research Design; Sulfonamides - administration & dosage; Sulfonamides - chemistry; Surface energy; Surface-Active Agents - chemistry; Tablets; Wettability; Wetting; Poorly soluble; Wetting; Disintegration; Agglomeration; Celecoxib; Porosity; Dispersion; Surface energy; Prostaglandin-endoperoxide synthase; Pharmaceutical technology; Enzyme; Vehicle(excipient); Enzyme inhibitor; Cyclooxygenase 2 inhibitor; Non steroidal antiinflammatory agent; Formulation; Dosage form; Tablet; Oxidoreductases