Regulation of the oncoprotein Smoothened by small molecules - Sharpe, Hayley J; Wang, Weiru; Hannoush, Rami N; de Sauvage, Frederic J (Nature chemical biology, 2015)
Keywords: 631/136; 631/67/1059; 631/80/86; 631/92/613; Allosteric Site; Amino Acid Sequence; Animals; Biochemical Engineering; Biochemistry; Bioorganic Chemistry; Cell Biology; Cell Membrane - metabolism; Chemistry; Chemistry/Food Science; Drosophila; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Ligands; Mice; Molecular biology; Molecular Conformation; Molecular Sequence Data; Mutation; Neoplasms - genetics; Neoplasms - metabolism; Patched Receptors; perspective; Protein Binding; Protein expression; Protein Structure, Tertiary; Receptors, Cell Surface - genetics; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism; Sequence Homology, Amino Acid; Signal transduction; Smoothened Receptor; Sterols - chemistry; Veratrum Alkaloids - chemistry