ENaC subunit-subunit interactions and inhibition by syntaxin 1A

• Published in: American journal of physiology. Renal physiology Vol. 286; no. 6; pp. F1100 - F1106
• Main Authors: Berdiev, Bakhrom K., Jovov, Biljana, Tucker, Ward C., Naren, Anjaparavanda P., Fuller, Catherine M., Chapman, Edwin R., Benos, Dale J.
• Format: Journal Article
• Language: English
• Published: United States 01.06.2004
• Subjects: Animals; Antigens, Surface - physiology; Blotting, Western; Cell Line; Cytoplasm - drug effects; Cytoplasm - metabolism; Dogs; Electrophoresis, Polyacrylamide Gel; Electrophysiology; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Epithelial Sodium Channels; Immunohistochemistry; Kidney - drug effects; Kidney - metabolism; Lipid Bilayers; Nerve Tissue Proteins - physiology; Precipitin Tests; Protein Biosynthesis - genetics; RNA, Complementary - biosynthesis; RNA, Complementary - genetics; Sodium Channel Blockers; Sodium Channels - drug effects; Sodium Channels - genetics; Sodium Channels - metabolism; Syntaxin 1; Transcription, Genetic; Transfection

Amiloride-sensitive epithelial Na + channels (ENaCs) are subject to modulation by many factors. Recent data have also linked the N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) machinery to this regulation of ENaC, but the molecular mechanisms that underlie this modulation are...