Injectable block copolymer hydrogels for sustained release of a PEGylated drug

• Published in: International journal of pharmaceutics Vol. 348; no. 1; pp. 95 - 106
• Main Authors: Yu, Lin, Chang, Guang Tao, Zhang, Huan, Ding, Jian Dong
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 04.02.2008; Elsevier
• Subjects: Animals; Antineoplastic Agents, Phytogenic - administration & dosage; Antineoplastic Agents, Phytogenic - pharmacokinetics; Antineoplastic Agents, Phytogenic - therapeutic use; Biological and medical sciences; Biological Availability; Block copolymer; Camptothecin (CPT); Camptothecin - administration & dosage; Camptothecin - pharmacokinetics; Camptothecin - therapeutic use; Delayed-Action Preparations - chemical synthesis; Delayed-Action Preparations - chemistry; Drug Delivery Systems - methods; General pharmacology; Glycolates - chemistry; Hydrogels - chemistry; Injectable hydrogel; Injections, Subcutaneous; Kinetics; Lactic Acid; Medical sciences; Mice; Mice, Inbred Strains; Microscopy, Electron, Transmission; PEGylation; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Phase Transition; Polyethylene Glycols - chemistry; Polyglycolic Acid; Sarcoma 180 - drug therapy; Sarcoma 180 - pathology; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectroscopy, Fourier Transform Infrared; Sustained release; Transition Temperature; Viscosity; Sustained release; PEGylation; Injectable hydrogel; Block copolymer; Camptothecin (CPT); Antineoplastic agent; Drug; Pharmaceutical technology; Enzyme; Controlled release form; DNA topoisomerase; Enzyme inhibitor; Colloidal gel; Alkaloid; Isomerases; Dosage form; Hydrogel; Pegylated form; Topoisomerase I inhibitor

The paper employs the spontaneous physical gelling property of a biodegradable polymer in water to prepare an injectable sustained release carrier for a PEGylated drug. A series of thermogelling PLGA–PEG–PLGA triblock copolymers were synthesized. The PEGylated camptothecin (CPT) was also prepared an...