The Role of Glypican-1 in the Tumour Microenvironment

• Published in: Advances in experimental medicine and biology Vol. 1245; p. 163
• Main Authors: Lund, Maria E, Campbell, Douglas H, Walsh, Bradley J
• Format: Journal Article
• Language: English
• Published: United States 01.01.2020
• Subjects: Epithelial-Mesenchymal Transition; Glypicans - metabolism; Humans; Neoplasms - drug therapy; Neoplasms - metabolism; Neoplasms - pathology; Signal Transduction; Tumor Microenvironment; Angiogenesis; GPC-1; Glypican-1; Growth factor signalling; Pancreatic cancer; Therapeutics; Stroma; Metastasis; Invasion; Tumour microenvironment

Glypican-1 (GPC-1) is a cell surface heparan sulphate proteoglycan that is critical during normal development, but which is not required for normal homoeostasis in the adult. It is, however, overexpressed in a variety of solid tumours and is known to regulate tumour growth, invasion, metastasis and...