Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling

• Published in: American journal of physiology: Gastrointestinal and liver physiology Vol. 320; no. 4; pp. G450 - G463
• Main Authors: Li, Shao-Wei, Takahara, Terumi, Que, Weitao, Fujino, Masayuki, Guo, Wen-Zhi, Hirano, Shin-Ichi, Ye, Li-Ping, Li, Xiao-Kang
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.04.2021
• Subjects: Adenosine kinase; Alanine; Alanine transaminase; Amino acids; AMP; Animals; Aspartate aminotransferase; Carbon dioxide; Choline; Cytokines; Drinking water; Fat metabolism; Fatty liver; Fibrosis; Heme; Heme oxygenase (decyclizing); Heme Oxygenase-1 - metabolism; Hepatocytes; Hepatocytes - drug effects; Hepatocytes - enzymology; Hepatocytes - pathology; Hydrogen; Hydrogen - chemistry; Hydrogen - pharmacology; Inflammation; Interleukin 10; Interleukin-10 - metabolism; Kinases; Kupffer Cells - drug effects; Kupffer Cells - metabolism; Lipid metabolism; Lipogenesis; Lipolysis - drug effects; Lipopolysaccharides; Liver; Liver - drug effects; Liver - enzymology; Liver - pathology; Liver Cirrhosis, Experimental - enzymology; Liver Cirrhosis, Experimental - pathology; Liver Cirrhosis, Experimental - prevention & control; Liver diseases; Male; Membrane Proteins - metabolism; Metabolism; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease - enzymology; Non-alcoholic Fatty Liver Disease - pathology; Non-alcoholic Fatty Liver Disease - prevention & control; Oral administration; Palmitic acid; Protein kinase; RAW 264.7 Cells; Signal Transduction; Sirtuin 1 - metabolism; Water - pharmacology; sirtuin 1; fatty liver; fibrosis; heme oxygenase-1; hydrogen-rich water

The mRNA expression of inflammatory cytokines in the HRW group was lower than in the CSAA group. HRW reversed hepatocyte apoptosis as well as hepatic inflammation and fibrosis in NASH specimens. Molecular hydrogen inhibits LPS-induced inflammation via an HO-1/IL-10-independent pathway. HRW improved...