Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling - Li, Shao-Wei; Takahara, Terumi; Que, Weitao; Fujino, Masayuki; Guo, Wen-Zhi; Hirano, Shin-Ichi; Ye, Li-Ping; Li, Xiao-Kang (American journal of physiology: Gastrointestinal and liver physiology, 2021)
Keywords: Adenosine kinase; Alanine; Alanine transaminase; Amino acids; AMP; Animals; Aspartate aminotransferase; Carbon dioxide; Choline; Cytokines; Drinking water; Fat metabolism; Fatty liver; Fibrosis; Heme; Heme oxygenase (decyclizing); Heme Oxygenase-1 - metabolism; Hepatocytes; Hepatocytes - drug effects; Hepatocytes - enzymology; Hepatocytes - pathology; Hydrogen; Hydrogen - chemistry; Hydrogen - pharmacology; Inflammation; Interleukin 10; Interleukin-10 - metabolism; Kinases; Kupffer Cells - drug effects; Kupffer Cells - metabolism; Lipid metabolism; Lipogenesis; Lipolysis - drug effects; Lipopolysaccharides; Liver; Liver - drug effects; Liver - enzymology; Liver - pathology; Liver Cirrhosis, Experimental - enzymology; Liver Cirrhosis, Experimental - pathology; Liver Cirrhosis, Experimental - prevention & control; Liver diseases; Male; Membrane Proteins - metabolism; Metabolism; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease - enzymology; Non-alcoholic Fatty Liver Disease - pathology; Non-alcoholic Fatty Liver Disease - prevention & control; Oral administration; Palmitic acid; Protein kinase; RAW 264.7 Cells; Signal Transduction; Sirtuin 1 - metabolism; Water - pharmacology; sirtuin 1; fatty liver; fibrosis; heme oxygenase-1; hydrogen-rich water