Biogated mesoporous silica nanoagents for inhibition of cell migration and combined cancer therapy

• Published in: Mikrochimica acta (1966) Vol. 191; no. 6; p. 326
• Main Authors: Wu, Yu, Shi, Xiao-Jie, Dai, Xin-Yi, Song, Tian Shun, Li, Xiang-Ling, Xie, Jing Jing
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.06.2024; Springer; Springer Nature B.V
• Subjects: A549 Cells; Analytical Chemistry; Antimitotic agents; Antineoplastic agents; Cancer; Cancer therapies; Care and treatment; Cell Movement - drug effects; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Drug delivery systems; Drug Therapy, Combination - methods; Drugs; Gene therapy; Health aspects; Humans; Lung cancer; Lung cancer, Non-small cell; Metastasis; Microengineering; MicroRNA; Microscopy, Electron, Transmission; Nanochemistry; Nanoparticle Drug Delivery System - chemistry; Nanoparticle Drug Delivery System - therapeutic use; Nanoparticles - chemistry; Nanoparticles - therapeutic use; Nanoparticles - ultrastructure; Nanotechnology; Neoplasms - drug therapy; Oligonucleotides; Original Paper; Prevention; Silica; Silicon dioxide; Silicon Dioxide - chemistry; Tumors; Vehicles; miR-330-3p; Migratory inhibition; Biogate; MSNs; Synergistic therapy

Migration is an initial step in tumor expansion and metastasis; suppressing cellular migration is beneficial to cancer therapy. Herein, we designed a novel biogated nanoagents that integrated the migration inhibitory factor into the mesoporous silica nanoparticle (MSN) drug delivery nanosystem to re...