Interstitial cells of Cajal and human colon motility in health and disease

• Published in: American journal of physiology: Gastrointestinal and liver physiology Vol. 321; no. 5; pp. G552 - G575
• Main Authors: Huizinga, Jan D., Hussain, Amer, Chen, Ji-Hong
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.11.2021
• Subjects: Animal models; Animals; Autonomic Nervous System - physiopathology; Colon; Colon - innervation; Colon - metabolism; Colon - pathology; Colonic Diseases - metabolism; Colonic Diseases - pathology; Colonic Diseases - physiopathology; Colonic Pseudo-Obstruction - metabolism; Colonic Pseudo-Obstruction - pathology; Colonic Pseudo-Obstruction - physiopathology; Constipation; Constipation - metabolism; Constipation - pathology; Constipation - physiopathology; Defecation; Enteric nervous system; Enteric Nervous System - physiopathology; Fecal incontinence; Fecal Incontinence - metabolism; Fecal Incontinence - pathology; Fecal Incontinence - physiopathology; Gastric motility; Gastrointestinal Motility; Hirschsprung Disease - metabolism; Hirschsprung Disease - pathology; Hirschsprung Disease - physiopathology; Hirschsprung's disease; Humans; Interstitial cells; Interstitial cells of Cajal; Interstitial Cells of Cajal - metabolism; Interstitial Cells of Cajal - pathology; Manometry; Motility; Reflexes; Small intestine; constipation; manometry; colonic motility; HAPC; interstitial cells of Cajal; high-resolution colonic

Our understanding of human colonic motility, and autonomic reflexes that generate motor patterns, has increased markedly through high-resolution manometry. Details of the motor patterns are emerging related to frequency and propagation characteristics that allow linkage to interstitial cells of Caja...