Concomitant Infection with HTLV-I and HTLV-III in a Patient with T8 Lymphoproliferative Disease

• Published in: The New England journal of medicine Vol. 315; no. 17; pp. 1073 - 1078
• Main Authors: Harper, Mary E, Kaplan, Mark H, Marselle, Lisa M, Pahwa, Savita G, Chayt, Karen J, Sarngadharan, M.G, Wong-Staal, Flossie, Gallo, Robert C
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 23.10.1986
• Subjects: Aged; AIDS-Related Complex - complications; AIDS-Related Complex - microbiology; AIDS/HIV; Biological and medical sciences; Biopsy; Bone marrow; Cancer; Case reports; Cytokines; Deltaretrovirus - isolation & purification; Deltaretrovirus Infections - complications; Deltaretrovirus Infections - microbiology; Deoxyribonucleic acid; DNA; Enzymes; Genomes; Granulocytes; Hematologic and hematopoietic diseases; HIV - isolation & purification; Humans; Hybridization; Infections; Laboratories; Leukemia; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphocytes; Lymphoproliferative Disorders - complications; Lymphoproliferative Disorders - microbiology; Male; Medical sciences; Nucleic Acid Hybridization; T-Lymphocytes - microbiology; Human; Molecular hybridization; Immunopathology; Virological exploration; Retroviridae; Lymphadenopathy syndrome; Hemopathy; Infection; Virus; Lymphoproliferative syndrome; Viral disease; T-Lymphocyte; Human immunodeficiency virus; HTLV-I virus; Lymphocytosis
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM198610233151707

All currently known human retroviruses are T-cell lymphotropic viruses (HTLVs) and primarily infect T 4 cells (reviewed by Wong-Staal and Gallo 1 ). HTLV-I immortalizes normal T lymphocytes in vitro, and in vivo is associated with adult T-cell leukemia/lymphoma 2 3 4 5 as well as other T 4 neoplasms with various clinicopathological names. 6 HTLV-II also transforms T 4 cells, but has been detected only rarely in milder forms of leukemia 7 (and Salahuddin Z, Gallo RC: unpublished data). In contrast, HTLV-III (human immunodeficiency virus) is cytopathic to its target T 4 cell and is the etiologic agent of the acquired immunodeficiency syndrome (AIDS). 8 9 10 11 12 HTLV-IV, more . . .