Attention to age: similar dosing regimens lead to different vancomycin levels among older and younger patients

• Published in: Age and ageing Vol. 49; no. 1; pp. 26 - 31
• Main Authors: Yahav, Dafna, Abbas, Maria, Nassar, Laila, Ghrayeb, Alia, Shepshelovich, Daniel, Kurnik, Daniel, Leibovici, Leonard, Paul, Mical
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.01.2020; Oxford Publishing Limited (England)
• Subjects: Age differences; Antibiotics; Dosage; Drug resistance; Glomerular filtration rate; Infections; Methicillin; Minimum inhibitory concentration; Mortality; Mortality rates; MRSA; Older people; Prospective studies; Staphylococcus aureus; Staphylococcus infections; Toxicity; Vancomycin; vancomycin; infection; older people; trough levels; methicillin resistant Staphylococcus aureus (MRSA)

Abstract Background little is known on the clinical implications of vancomycin trough levels among older patients. Objective to evaluate the association between vancomycin levels and outcomes among older versus younger patients. Design retrospective study. Subjects patients aged 18–64 and ≥65 years...